Effect of photosensitization reaction on myelinated or unmyelinated nerve
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- TAKAHASHI Haruka
- School of Fundamental Science and Technology, Graduate School of Science and Technology, Keio University
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- HAMADA Risa
- School of Fundamental Science and Technology, Graduate School of Science and Technology, Keio University
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- OGAWA Emiyu
- School of Fundamental Science and Technology, Graduate School of Science and Technology, Keio University
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- ARAI Tsunenori
- School of Fundamental Science and Technology, Graduate School of Science and Technology, Keio University Department of Applied Physics and Physico-Informatics, Faculty of Science and Technology, Keio University
抄録
<p>To investigate nerve injury by a photosensitization reaction ex vivo, we observed an uptake of talaporfin sodium into crayfish nerve and porcine phrenic nerve, and measured electrophysiological conduction velocity of the crayfish nerve during the reaction. We found the drug uptake of inside the perineurium was lower than that of outside in porcine phrenic nerve. The crayfish nerve was immersed into 20 μg/ml talaporfin sodium for 15 min and irradiated by a 663 nm laser light with 120 mW/cm2. Since we found the measured conduction velocity was decreased increasing the irradiation time, the nerve might not be resistant to the photosensitization reaction at atmospheric oxygen environment. It was reported that the phrenic nerve was intact when an electro blockade using photosensitization reaction was performed in vivo animal experiment. Low uptake of talaporfin sodium inside the perineurium and low oxygen partial pressure of nerve might be the mechanism to preserve phrenic nerve in vivo animal experiment.</p>
収録刊行物
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- 生体医工学
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生体医工学 55Annual (Proc), 574-575, 2017
公益社団法人 日本生体医工学会
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詳細情報 詳細情報について
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- CRID
- 1390282680247124480
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- NII論文ID
- 130006077276
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- ISSN
- 18814379
- 1347443X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可