Longitudinal study on the effectiveness of vitamin D supplements in exclusively breast-fed infants
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- Terashita Shintaro
- Department of Pediatrics, Toyama Prefectural Central Hospital, Toyama, Japan Department of Pediatrics, University Toyama, Toyama, Japan
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- Nakamura Taichi
- Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
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- Igarashi Noboru
- Department of Pediatrics, Toyama Prefectural Central Hospital, Toyama, Japan
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<p>Vitamin D deficiency is a common health problem in infancy. Breast-fed infants are at a higher risk of rickets than formula-fed infants. We observed fluctuations in vitamin D levels in infancy (phase I, 2009–2010) and considered the benefits of vitamin D supplementation specifically in exclusively breast-fed infants in Japan (phase II, 2015). Infants born at our hospital were enrolled in this study. In phase I, we measured 25-hydroxyvitamin D [25(OH)D] levels at 1- to 6-mo intervals from birth. In phase II, we measured 25(OH)D levels before and after supplementation. Vitamin D deficiency was defined as 25(OH)D levels of < 20 ng/mL. All 38 infants in phase I were deficient at birth, and none of the exclusively breast-fed infants achieved 25(OH)D sufficiency by 5 mo of age. Formula-fed infants achieved 25(OH)D sufficiency earlier. The majority of the 71 infants in phase II were deficient at birth. We recommended an oral vitamin D supplement at a daily dose of 4.0 µg for the 15 exclusively breast-fed infants, starting at 1 mo of age; 14 (93.3%) of them achieved 25(OH)D sufficiency by 5 months of age. Exclusively breast-fed infants are at a high risk of vitamin D deficiency; adequate supplementation is an effective preventative strategy.</p>
収録刊行物
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- Clinical Pediatric Endocrinology
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Clinical Pediatric Endocrinology 26 (4), 215-222, 2017
日本小児内分泌学会
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詳細情報
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- CRID
- 1390001204482726912
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- NII論文ID
- 130006105768
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- ISSN
- 13477358
- 09185739
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- 抄録ライセンスフラグ
- 使用不可