交互累積膜法による高機能性高分子ナノ薄膜の開発

• 吉田 健太郎

  奥羽大学薬学部

書誌事項

タイトル別名

• Development of Functional Thin Polymer Films Using a Layer-by-Layer Deposition Technique
• コウゴ ルイセキマクホウ ニ ヨル コウキノウセイ コウブンシ ナノ ハクマク ノ カイハツ

抄録

 Functional thin films containing insulin were prepared using layer-by-layer (LbL) deposition of insulin and negatively- or positively-charged polymers on the surface of solid substrates. LbL films composed of insulin and negatively-charged polymers such as poly(acrylic acid) (PAA), poly(vinylsulfate) (PVS), and dextran sulfate (DS) were prepared through electrostatic affinity between the materials. The insulin/PAA, insulin/PVS, and insulin/DS films were stable in acidic solutions, whereas they decomposed under physiological conditions as a result of a change in the net electric charge of insulin from positive to negative. Interestingly, the insulin-containing LbL films were stable even in the presence of a digestive-enzyme (pepcin) at pH 1.4 (stomach pH). In contrast, LbL films consisting of insulin and positively-charged polymers such as poly(allylamine hydrochloride) (PAH) decomposed in acidic solutions due to the positive charges of insulin generated in acidic media. The insulin-containing LbL films can be prepared not only on the surface of flat substrates, such as quartz slides, but also on the surface of microparticles, such as poly(lactic acid) (PLA) microbeads. Thus, insulin-containing LbL film-coated PLA microbeads can be handled as a powder. In addition, insulin-containing microcapsules were prepared by coating LbL films on the surface of insulin-doped calcium carbonate (CaCO₃) microparticles, followed by dissolution of the CaCO₃ core. The release of insulin from the microcapsules was accelerated at pH 7.4, whereas it was suppressed in acidic solutions. These results suggest the potential use of insulin-containing microcapsules in the development of oral formulations of insulin.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 137 (10), 1215-1221, 2017-10-01

  公益社団法人 日本薬学会

キーワード

• layer-by-layer
• drug delivery system
• microcapsule

詳細情報

• CRID: 1390001206217185792
• NII論文ID: 130006109884
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.17-00128
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 028573173
• PubMed: 28966262
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028573173
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/137/10/137_17-00128/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2017406474
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可