Comparison of the Benefit Feeling Rate Based on the Sho of OTC Kakkonto, Cold Remedy and Cold Remedy with Kakkonto Combination Product

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  • Okita Mitsuyoshi
    Josai University Pharmacy
  • Yayoshi Yuki
    Department of Analytical Pharmaceutics and Informatics, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University
  • Ohara Kousuke
    Laboratory of Drug Metabolism, Faculty of Pharmaceutical Sciences, Josai International University
  • Negishi Akio
    Department of Analytical Pharmaceutics and Informatics, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University
  • Akimoto Hayato
    Department of Analytical Pharmaceutics and Informatics, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University
  • Inoue Naoko
    Josai University Pharmacy Laboratory of Pharmacy Management, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University
  • Numajiri Sachihiko
    Laboratory of Pharmacy Management, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University
  • Ohshima Shigeru
    Josai University Pharmacy Laboratory of Pharmacy Management, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University
  • Honma Seiichi
    Onko-Do Kampo Akebono Yakkyoku Co., Ltd.
  • Oshima Shinji
    Department of Analytical Pharmaceutics and Informatics, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University
  • Kobayashi Daisuke
    Josai University Pharmacy Department of Analytical Pharmaceutics and Informatics, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University

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<p>Kakkonto (KK), a traditional Japanese Kampo formulation for cold and flu, is generally sold as an OTC pharmaceuticals used for self-medication. Kampo formulations should be used according to the Sho-symptoms of Kampo medicine. These symptoms refer to the subjective symptoms themselves. Although with OTC pharmaceuticals, this is often not the case. We surveyed the relationship of agreement of Sho with the benefit feeling rate (BFR) of patients who took KK (n=555), cold remedies with KK (CK, n=315), and general cold remedies (GC, n=539) using internet research. BFR of a faster recovery was greater in participants who took the medication early and who had confidence in their physical strength in all treatment groups. BFR was significantly higher in the GC group than in the KK group for patients with headache, runny nose, blocked nose, sneezing, and cough. BFR was also significantly higher in the GC group than in the CK group for headache (males) and cough (females). BFR was the highest in the KK group for stiff shoulders. All cold remedies were more effective when taken early, and the larger the number of Sho that a patient had, the greater the BFR increased. Therefore, a cold remedy is expected to be most effective when there are many cold symptoms and when it is taken at an early stage of the common cold.</p>

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