Internal Structures of the Globus Pallidus in Patients with Parkinson’s Disease: Evaluation with Phase Difference-enhanced Imaging
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- Ide Satoru
- Department of Radiology, University of Occupational and Environmental Health, School of Medicine
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- Kakeda Shingo
- Department of Radiology, University of Occupational and Environmental Health, School of Medicine
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- Yoneda Tetsuya
- Department of Medical Physics in Advanced Biomedical Sciences, Faculty of Life Sciences, Kumamoto University
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- Moriya Junji
- Department of Radiology, University of Occupational and Environmental Health, School of Medicine
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- Watanabe Keita
- Department of Radiology, University of Occupational and Environmental Health, School of Medicine
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- Ogasawara Atsushi
- Department of Radiology, University of Occupational and Environmental Health, School of Medicine
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- Futatsuya Koichiro
- Department of Radiology, University of Occupational and Environmental Health, School of Medicine
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- Ohnari Norihiro
- Department of Radiology, University of Occupational and Environmental Health, School of Medicine
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- Sato Toru
- Department of Radiology, University of Occupational and Environmental Health, School of Medicine
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- Hiai Yasuhiro
- Department of Medical Physics in Advanced Biomedical Sciences, Faculty of Life Sciences, Kumamoto University
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- Matsuyama Atsuji
- Department of Pathology and Oncology, University of Occupational and Environmental Health, School of Medicine
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- Fujiwara Hitoshi
- Department of Surgical Pathology, University of Occupational and Environmental Health, School of Medicine
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- Hisaoka Masanori
- Department of Pathology and Oncology, University of Occupational and Environmental Health, School of Medicine
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- Korogi Yukunori
- Department of Radiology, University of Occupational and Environmental Health, School of Medicine
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抄録
<p>Purpose: The medial medullary lamina (MML) separates the medial globus pallidus (GPm) from the lateral. The aim of this study was to assess the changes in appearance of MML related to age using the phase difference-enhanced (PADRE) imaging and to determine whether PADRE can depict the MML in the patients with Parkinson’s disease (PD).</p><p>Materials and Methods: We enrolled 20 patients with PD and 50 normal control subjects (NC). First, for the visualization of the MML in the NC, we compared the PADRE, susceptibility-weighted imaging (SWI)-like images and T2 weighted imaging (WI) by using multiple comparison. The grading methods are as follows: grade 1; MML was not delineated, grade 2; less than half of MML was delineated, grade 3; more than half of MML was delineated and grade 4; whole MML was clearly delineated. We determined grade 3 and 4 as good depiction, delineating the GPm. Then, we evaluated patients with PD using the same method.</p><p>Results: In NC, the delineation of MML was good in 84% of cases on PADRE, but only 34% of cases showed a good depiction on SWI-like images (average grading score 3.31 vs 2.11, P < 0.05). No MML was delineated in all cases on T2 WI. Although younger subjects tended to show whole MML clearly, a part of MML tends to be obscured with age on PADRE. In patients with PD the depiction of MML on PADRE was also good in 90% of cases.</p><p>Conclusion: The PADRE technique facilitates the depiction of the MML within globus pallidus (GP) on a broad range of age NC and patients with PD and it is superior to SWI-like images and T2 WI.</p>
収録刊行物
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- Magnetic Resonance in Medical Sciences
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Magnetic Resonance in Medical Sciences 16 (4), 304-310, 2017
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