Dynamics of Oxidative Stress Evoked by Myocardial Ischemia Reperfusion After Off-Pump Coronary Artery Bypass Grafting Elucidated by Bilirubin Oxidation

DOI Web Site Web Site PubMed 参考文献33件
  • Yamamoto Masaki
    Departments of Surgery 2 and Cardiovascular Surgery, Kochi Medical School
  • Nishimori Hideaki
    Departments of Surgery 2 and Cardiovascular Surgery, Kochi Medical School
  • Fukutomi Takashi
    Departments of Surgery 2 and Cardiovascular Surgery, Kochi Medical School
  • Yamaguchi Tokio
    Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University
  • Orihashi Kazumasa
    Departments of Surgery 2 and Cardiovascular Surgery, Kochi Medical School

この論文をさがす

抄録

<p>Background:Revascularization therapy relieves myocardial ischemia, but can also result in ischemia-reperfusion injury caused by oxidative stress. However, the biokinetics of oxidative stress after myocardial ischemia-reperfusion are uncertain. This study aimed to evaluate the dynamics of oxidative stress after off-pump coronary artery bypass grafting (OPCAB) by measuring urinary biopyrrin levels. Biopyrrin is an oxidative metabolite of bilirubin thought to reflect oxidative stress, along with reactive nitrogen species (RNS).</p><p>Methods and Results:The study included 18 patients who underwent OPCAB; patients were divided into effort angina pectoris (EAP; n=11) and unstable angina pectoris (UAP; n=7). Urinary biopyrrin and RNS levels were measured during the perioperative period (≤48 h after surgery). Biopyrrin levels transiently increased 4–12 h post-surgery (early phase), followed by a prolonged increase approximately 24–32 h post-surgery (late phase). The delayed increase in biopyrrin tended to be higher in patients with UAP, with a simultaneous increase in RNS. The patients in the UAP group had generally high pulmonary capillary wedge pressure (PCWP), although the cardiac index was within a normal range during the delay phase.</p><p>Conclusions:The dynamics of biopyrrin levels revealed a biphasic pattern of oxidative stress after OPCAB. Delayed production of oxidative stress may be influenced by preoperative severity of myocardial ischemia and delayed RNS production.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 81 (11), 1678-1685, 2017

    一般社団法人 日本循環器学会

参考文献 (33)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ