Diversity of Secondary Metabolites from Some Medicinal Plants and Cultivated Lichen Mycobionts

• Tanahashi Takao

  Kobe Pharmaceutical University

Bibliographic Information

Other Title

• 薬用植物及び単離培養地衣菌の二次代謝物の多様性
• ヤクヨウ ショクブツ オヨビ タンリ バイヨウ チイキン ノ ニジ タイシャブツ ノ タヨウセイ

Abstract

 Studies on the structural determination, biosynthesis, and biological activities of secondary metabolites from natural sources are significant in the field of natural products chemistry. This review focuses on diverse secondary metabolites isolated from medicinal plants and cultivated mycobionts of lichens in our laboratory. Monoterpene-tetrahydroisoquinoline glycosides and alkaloids isolated from Cephaelis acuminata and Alangium lamarckii gave important information on the biosynthesis of ipecac alkaloids. A variety of glycosides linked with a secologanin unit and indole alkaloids were obtained from medicinal plants belonging to the families of Rubiaceae, Apocynaceae, and Loganiaceae. Plant species of the four genera Fraxinus, Syringa, Jasminum, and Ligustrum of the family Oleaceae were chemically investigated to provide several types of secoiridoid and iridoid glucosides. The biosynthetic pathway leading from protopine to benzophenanthridine alkaloids in suspension cell cultures of Eschscholtzia californica was elucidated. The structures and biological activities of the bisbenzylisoquinoline alkaloids of Stephania cepharantha and Nelumbo nucifera were also investigated. In addition, the mycobionts of lichens were cultivated to afford various types of metabolites that differ from the lichen substances of intact lichens but are structurally similar to fungal metabolites. The biosynthetic origins of some metabolites were also studied. These findings suggest that cultures of lichen mycobionts could be sources of new bioactive compounds and good systems for investigating secondary metabolism in lichens.<br>

Journal

• YAKUGAKU ZASSHI

  YAKUGAKU ZASSHI 137 (12), 1443-1482, 2017-12-01

  The Pharmaceutical Society of Japan

Keywords

• secondary metabolite
• medicinal plant
• cultivated lichen mycobiont
• structure determination
• biosynthesis
• biological acitivity

Details

• CRID: 1390282681193390336
• NII Article ID: 130006236537
• NII Book ID: AN00284903
• DOI: 10.1248/yakushi.17-00147
• ISSN: 13475231
• ISSN: 00316903
• NDL BIB ID: 028720981
• PubMed: 29199255
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028720981
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/137/12/137_17-00147/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018063437
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed