The palatomaxillary suture revisited: A histological and immunohistochemical study using human fetuses
-
- KIM Ji Hyun
- Department of Anatomy, Seonam University College of Medicine
-
- YAMAMOTO Masahito
- Department of Anatomy, Tokyo Dental College
-
- ABE Hiroshi
- Department of Anatomy, Akita University School of Medicine
-
- MURAKAMI Gen
- Department of Anatomy, Tokyo Dental College Division of Internal Medicine, Iwamizawa Asuka Hospital
-
- SHIBATA Shunichi
- Department of Maxillofacial Anatomy, Graduate School of Tokyo Medical and Dental University
-
- RODRÍGUEZ-VÁZQUEZ Jose Francisco
- Department of Anatomy and Human embryology, Institute of Embryology, Faculty of Medicine, Complutense University
-
- ABE Shin-ichi
- Department of Anatomy, Tokyo Dental College
抄録
<p>In human fetuses, the palatine process of the maxilla is attached to the inferior aspect of the horizontal plate of the palatine bone (HPPB). The fetal palatomaxillary suture is so long that it extends along the anteroposterior axis rather than along the transverse axis. The double layered bony palate disappears in childhood and the transverse suture is formed. To better understand the development of the double layered bone palate, we examined histological sections obtained from 25 fetuses of gestational age 9-11, 16-18 and 30 weeks. The double layered palate was seen in all of the specimens examined. Inferior angulation of the posterior end of the HPPB was evident at 9-11 weeks, but the initial palatine aponeurosis did not attach to the angulation but to a slightly anterior site. Both the maxilla and the HPPB were tightly attached to the vomer at 16-18 weeks. In both bones, bilateral plates met at the midline. The palatomaxillary suture was filled with short, randomly arranged collagen fibers. The nasal end of the suture was covered by a tight periosteum. Immunohistochemical examination of 3 fetuses at 16-18 weeks showed: 1) no expression of versican, tenascin-c or type II collagen in the suture; 2) few mitotic cells positive for proliferating cell nuclear antigen; 3) no or few CD34-positive developing vessels; and 4) no CD68-positive macrophages. These findings suggested that the fetal palatomaxillary suture was inactive for reconstruction and growth and that soft palate muscles likely did not contribute to the development of the double layered configuration.</p>
収録刊行物
-
- Ｏｋａｊｉｍａｓ Ｆｏｌｉａ Ａｎａｔｏｍｉｃａ Ｊａｐｏｎｉｃａ
-
Ｏｋａｊｉｍａｓ Ｆｏｌｉａ Ａｎａｔｏｍｉｃａ Ｊａｐｏｎｉｃａ 94 (2), 65-74, 2017
オカジマ・フォリア・アナトミカ・ヤポニカ編集部