A Case of Metastatic Basal Cell Carcinoma Treated with Cisplatin and Adriamycin
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- Kanzaki Akiko
- Department of Dermatology, Nippon Medical School
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- Ansai Shin-ichi
- Division of Dermatology, Nippon Medical School Musashi Kosugi Hospital
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- Ueno Takashi
- Department of Dermatology, Nippon Medical School
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- Kawana Seiji
- Department of Dermatology, Nippon Medical School
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- Shimizu Akira
- Division of Diagnostic Pathology, Nippon Medical School
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- Naito Zenya
- Division of Diagnostic Pathology, Nippon Medical School
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- Saeki Hidehisa
- Department of Dermatology, Nippon Medical School
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<p>A 72-year-old man was referred to our hospital for treatment of an ulcer that had been growing on his back for 10 years. Physical examination showed an ulcerated tumor from the neck to the back and swollen cervical lymph nodes. The tumor size was 12×9 cm. Histology of the biopsy showed a nodular and morpheic basal cell carcinoma (BCC). A chest computed tomography (CT) scan showed multiple lung tumors. CT-guided biopsy of the lung and the cervical lymph node revealed metastatic basal cell carcinoma (MBCC). The primary skin tumor was resected and a total of 10 courses of cisplatin (25 mg/m2/day×75%) and adriamycin (50 mg/m2×75%) were administered for metastatic basal cell carcinoma (MBCC). The patient died 5 years and 3 months after his first visit. Autopsy revealed MBCC in the lung, kidney, pancreas, several lymph nodes, liver and bone. A portion of the tumor cells were composed of squamoid cells with eosinophilic cytoplasm, large nuclei, lack of the characteristic peripheral palisading and retraction artifacts, and variable cytoplasmic keratinization. These pathological findings were compatible with basosquamous cell carcinoma. Chemotherapy was effective for MBCC in this patient.</p>
収録刊行物
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- 日医大誌
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日医大誌 84 (6), 286-290, 2017
日本医科大学医学会