Antihypertensive Effect of γ-Aminobutyric Acid-Enriched Brown Rice on Spontaneously Hypertensive Rats

• KAWAKAMI Kohei

  Department of Experimental Animals, Interdisciplinary Center for Science Research, Organization for Research, Shimane University

• YAMADA Kazuo

  Department of Legal Medicine, Faculty of Medicine, Shimane University

• YAMADA Takaya

  Department of Experimental Animals, Interdisciplinary Center for Science Research, Organization for Research, Shimane University

• NABIKA Toru

  Department of Functional Pathology, Faculty of Medicine, Shimane University

• NOMURA Masato

  Department of Biotechnology and Chemistry, School of Engineering, Kinki University

抄録

‘Haiibuki’ is a giant embryo rice cultivar that contains abundant γ-aminobutyric acid (GABA) compared with conventional rice cultivars. Here, we performed a functional evaluation of ‘GABA-enriched brown rice’ (GEBR) prepared by modifying the ‘Haiibuki’ cultivar to contain more GABA. Study 1: Spontaneously hypertensive rats were divided into three groups [control (cornstarch), normal brown rice, and GEBR] and fed an orally administered diet for 4 wk. A significant blood pressure elevation-inhibitory effect was observed in the GEBR group as compared with the other groups. Study 2: Rats were divided into two groups and fed ad libitum for 12 wk. The two groups were control (commercial feed with 5% cornstarch) and GEBR (commercial feed with 5% GEBR). Body weight, blood pressure, food consumption, and water intake were measured during the study period, and blood chemistry was analyzed after the study. Plasma 8-hydroxy-2′-deoxyguanosine (8-OHdG) and urinary isoprostane were measured 12 and 10 wk after the start of the study, respectively. A significant blood pressure elevation-inhibitory effect was observed in the GEBR group. The 8-OHdG and isoprostane levels were significantly lower in the GEBR group than in the control group, demonstrating an oxidative stress-reducing effect. Therefore, GEBR exhibited a blood pressure elevation-inhibitory effect under the conditions of this study. The antioxidative action may occur secondarily to the antihypertensive action of GABA, suggesting that the long-term ad libitum ingestion of GEBR prevents hypertension. A reduction in oxidative stress could reduce the chances of complications in cardiovascular diseases.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 64 (1), 56-62, 2018

  一般財団法人 学会誌刊行センター

キーワード

• γ-aminobutyric acid (GABA)
• spontaneously hypertensive rat (SHR)
• blood pressure
• giant embryo rice
• anti-oxidation

詳細情報

• CRID: 1390282681300676096
• NII論文ID: 130006405214
• NII書誌ID: AA00703822
• DOI: 10.3177/jnsv.64.56
• ISSN: 18817742
• ISSN: 03014800
• NDL書誌ID: 029130270
• PubMed: 29491273
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029130270
• Web Site: https://www.jstage.jst.go.jp/article/jnsv/64/1/64_56/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018288764
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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