Preparative Separation of High-Purity Dihydroartemisinic Acid from Artemisinin Production Waste by Combined Chromatography

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  • Liu Shuoqian
    Department of Tea Science, College of Horticulture and Hardening, Hunan Agricultural University National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals
  • Ferreira Jorge Freire da Silva
    U.S. Salinity Laboratory, United States Department of Agriculture Agricultural Research Service
  • Tian Dongming
    National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals
  • Tang Yuwei
    Department of Tea Science, College of Horticulture and Hardening, Hunan Agricultural University
  • Liu Liping
    Department of Tea Science, College of Horticulture and Hardening, Hunan Agricultural University
  • Yang Wei
    National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals
  • Liu Zhonghua
    Department of Tea Science, College of Horticulture and Hardening, Hunan Agricultural University National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals
  • Tian Na
    Department of Tea Science, College of Horticulture and Hardening, Hunan Agricultural University

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<p>In order to make full use of artemisinin production waste and thus to reduce the production cost of artemisinin, we developed an efficient and scalable method to isolate high-purity dihydroartemisinic acid from artemisinin production waste by combining anion-exchange resin with silica-gel column chromatography. The adsorption and desorption characteristics of dihydroartemisinic acid on 10 types of anion-exchange resin were investigated, and the results showed that the 717 anion-exchange resin exhibited the highest capacity of adsorption and desorption to dihydroartemisinic acid. Adsorption isotherms were established for the 717 anion-exchange resin and they fitted well with both Langmuir and Freundlich model. Dynamic adsorption and desorption properties of 717 anion-exchange resin were characterized to optimize the chromatographic conditions. Subsequently, the silica-gel column chromatography was performed and dihydroartemisinic acid with a purity of up to 98% (w/w) was obtained. Finally, the scale-up experiments validated the preparative separation of high-purity dihydroartemisinic acid from industrial waste developed in the present work. This work presented for the first time an isolation of dihydroartemisinic acid with a purity of 98% from Artemisia annua (A. annua) by-product, which adds more value to this crop and has the potential to lower the prices of anti-malarial drugs.</p>

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