Case of Human Infection with Anaplasma phagocytophilum in Inner Mongolia, China

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  • Gaowa
    Inner Mongolia Key Laboratory of Tick-borne Zoonotic Infectious Disease, Department of Medicine, College of Hetao
  • Wulantuya
    Inner Mongolia Key Laboratory of Tick-borne Zoonotic Infectious Disease, Department of Medicine, College of Hetao
  • Yin Xuhong
    Inner Mongolia Key Laboratory of Tick-borne Zoonotic Infectious Disease, Department of Medicine, College of Hetao
  • Cao Minzhi
    Bayannur Centers for Disease Control and Prevention
  • Guo Shengchun
    Inner Mongolia Key Laboratory of Tick-borne Zoonotic Infectious Disease, Department of Medicine, College of Hetao
  • Ding Chunlian
    Inner Mongolia Key Laboratory of Tick-borne Zoonotic Infectious Disease, Department of Medicine, College of Hetao
  • Lu Yuhua
    Bayannur Centers for Disease Control and Prevention
  • Luo Jianchang
    Bayannur Centers for Disease Control and Prevention
  • Kawabata Hiroki
    Department of Bacteriology I, National Institute of Infectious Diseases
  • Ando Shuji
    Department of Virology I, National Institute of Infectious Diseases
  • Su Hongru
    Laboratory of Microbiology, Department of Food and Nutritional Sciences, Integrated Graduate School of Pharmaceutical and Nutritional Sciences, University of Shizuoka
  • Shimada Masahiko
    Laboratory of Microbiology, Department of Food and Nutritional Sciences, Integrated Graduate School of Pharmaceutical and Nutritional Sciences, University of Shizuoka
  • Takamoto Naoya
    Laboratory of Microbiology, Department of Food and Nutritional Sciences, Integrated Graduate School of Pharmaceutical and Nutritional Sciences, University of Shizuoka
  • Shimamura Yuk
    Laboratory of Microbiology, Department of Food and Nutritional Sciences, Integrated Graduate School of Pharmaceutical and Nutritional Sciences, University of Shizuoka
  • Masuda Shuichi
    Laboratory of Microbiology, Department of Food and Nutritional Sciences, Integrated Graduate School of Pharmaceutical and Nutritional Sciences, University of Shizuoka
  • Ohashi Norio
    Laboratory of Microbiology, Department of Food and Nutritional Sciences, Integrated Graduate School of Pharmaceutical and Nutritional Sciences, University of Shizuoka

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  • Case of Human Infection with <i>Anaplasma phagocytophilum</i> in Inner Mongolia, China

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<p>Anaplasma phagocytophilum is an obligate intracellular bacterium that causes febrile illness in humans and livestock. A 49-year-old woman was suffering from feverish symptoms, fatigue, arthralgia, general body pain, and anorexia for 2 weeks. Later, she visited the Bayannur Centers for Disease Control and Prevention Hospital in Inner Mongolia, China. Molecular-based diagnostic analysis of the patient’s blood revealed that A. phagocytophilum p44 DNA was positive, but Brucella omp31, spotted fever group Rickettsia gltA, Orientia tsutsugamushi 16S rDNA, and Ehrlichia p28 were negative. The amino acid sequences of 9 A. phagocytophilum p44 clones obtained from the patient shared 44–100% similarity among them and were closely related to those of previously identified p44 clones from Canis familiaris (accession no. KJV64194) and from Ixodes persulcatus tick (no. BAN28309). Serological tests using the patient’s serum showed that immunoglobulin M (IgM) and IgG titers to A. phagocytophilum antigens were 160 and 20, respectively, determined using indirect immunofluorescence assay, and the reaction to recombinant P44 proteins (rP44-1, rP44-18ES, and/or rP44-47) was confirmed using Western blot analysis. Thus, the results obtained in this study strongly suggest that the patient was infected with A. phagocytophilum. To our knowledge, this is the first case of human anaplasmosis infection in the Inner Mongolia Autonomous Region.</p>

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