Purinergic signaling in microglia in the pathogenesis of neuropathic pain

• INOUE Kazuhide

  Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University

抄録

Nerve injury often causes debilitating chronic pain, referred to as neuropathic pain, which is refractory to currently available analgesics including morphine. Many reports indicate that activated spinal microglia evoke neuropathic pain. The P2X4 receptor (P2X4R), a subtype of ionotropic ATP receptors, is upregulated in spinal microglia after nerve injury by several factors, including CC chemokine receptor CCR2, the extracellular matrix protein fibronectin in the spinal cord, interferon regulatory factor 8 (IRF8) and IRF5. Inhibition of P2X4R function suppresses neuropathic pain, indicating that microglial P2X4R play a key role in evoking neuropathic pain.

収録刊行物

• Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 93 (4), 174-182, 2017

  日本学士院

キーワード

• neuropathic pain
• spinal cord
• microglia
• purinergic signaling
• P2X4 receptor

詳細情報

• CRID: 1390001204145861632
• NII論文ID: 130006770747
• NII書誌ID: AA00785485
• DOI: 10.2183/pjab.93.011
• ISSN: 13492896
• ISSN: 03862208
• NDL書誌ID: 028138991
• PubMed: 28413195
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028138991
• Web Site: https://www.jstage.jst.go.jp/article/pjab/93/4/93_PJA9304B-02/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018007635
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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