Astaxanthin ameliorates ferric nitrilotriacetate-induced renal oxidative injury in rats

• Okazaki Yasumasa

  Department of Pathological Research, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine

• Okada Shigeru

  Department of Pathological Research, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Anti-Aging Food Sciences, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

• Toyokuni Shinya

  Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine

抄録

Daily intake of vegetables can reduce the risk of cancer and lifestyle-related diseases. However, supplementary intake of β-carotene alone has been reported to increase the risk of lung cancer in male cigarette smokers and people who were exposed to asbestos. The mechanism of the antioxidative properties of carotenoids in vivo, especially under oxidative stress conditions, still remains unclear. To investigate the antioxidant properties of dietary compounds, we examined the effects of chemically modified astaxanthin (Ax-C-8) using a rat model of ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative injury. Ax-C-8 demonstrated lethally toxic effects on the rats in a dose-dependent manner. Following supplementation with Ax-C-8 (0.02%, w/w) for 30 days, the rats were euthanized 1, 4 and 24 h after injection of Fe-NTA. After 4 h, Ax-C-8 pretreatment suppressed the elevation of creatinine and blood urea nitrogen and protected the rats from renal tubular necrosis and the formation of 4-hydroxy-2-nonenal-modified proteins. After 24 h, pretreatment with Ax-C-8 maintained the renal antioxidant enzyme levels and renal tubules. Here, we demonstrate the antioxidant effects of Ax-C-8 against Fe-NTA-induced oxidative injury in rats receiving a regular diet. These data suggest that dietary intake of astaxanthin may be useful for the prevention of renal tubular oxidative damage.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 61 (1), 18-24, 2017

  一般社団法人　日本酸化ストレス学会

キーワード

• astaxanthin
• ferric nitrilotriacetate
• oxidative stress
• vitamin E

詳細情報

• CRID: 1390001204670848896
• NII論文ID: 130006847650
• DOI: 10.3164/jcbn.16-114
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://www.jstage.jst.go.jp/article/jcbn/61/1/61_16-114/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018082233
• 本文言語コード: en
• データソース種別:
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