<b>Expression of IL-34 in Root Resorption by Excessive Orthodontic Force </b>

DOI Web Site 参考文献24件 オープンアクセス
  • Kohno Ryoko
    Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
  • Yamaguchi Masaru
    Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
  • Hikida Takuji
    Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
  • Kikuta Jun
    Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
  • Shimizu Mami
    Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
  • Takahashi-Hikida Momoko
    Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
  • Murakami Yoshiki
    Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
  • Kasai Kazutaka
    Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan

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<p>Interleukin-34(IL-34)was recently discovered and shown to mediate inflammation and osteoclastogenesis. An in vitro study reported that the expression of IL-34 is stimulated by tumor necrosis factor-α via nuclear factor-kB activation in osteoblasts. The present study focused on the expression of IL-34 in resorbed root cementum using an experimental rat model of tooth movement.</p><p>Experimental tooth movement was induced by a quad helix-type device. The upper first molar was palatally moved by the appliance with a force of 10 or 50g for 21 days. We performed hematoxylin and eosin and immunohistochemistry staining for tartrateresistant acid phosphatase and IL-34 in the root resorption area.</p><p>In the heavy force(50g)group, few IL-34-positive odontoclasts were observed on day 7 in the root, but increased at days 14 and 21. Therefore, IL-34 may take part in the aggravation of root resorption.</p>

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  • ＩＪＯＭＳ

    ＩＪＯＭＳ 16 (1), 8-15, 2017

    日本大学松戸歯学部 口腔科学研究所

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