フロログルシノール系條蟲駆除薬の合成研究 (第1報)

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タイトル別名
  • Syntheses of Phloroglucinol Derivatives as Anthelmintics against Tape-worms. I

抄録

In order to discover powerful anthelmintics for tape-worm, 8 kinds of acylated derivatives of phloroglucinol were synthesized, i.e. phlor-[aceto-, propio-, n-butylo-, n-valero, n-caprono-, oenantho-, benzo-, phenylaceto]-phenones., according to Hoesch's method. Clemmensen reduction of these compounds to 8 alkylated derivatives, i.e. ethyl-, n-butyl-, n-amyl-, n-hexyl-, n-heptyl-, benzyl- and phenylethyl-phlcroglucinol were made. As a preliminary tests for their anthelmintic properties, toxicity tests against earth worms and antibacterial actions against Staphylococcus aureus 209 P and Bacillus coli were carried out. Phloro-[n-caprono-, oenantho-, phenylaceto]-phenones and n-hexyl and n-heptyl-phloroglucinol showed strong toxicity and anti-bacterial actions against Staph. aureus. Of these 5 compounds, phloro-phenylacetophenone showed the strongest antibacterial power, being 85u/mg as against 1667u/mg of penicillin. However, none showed any efficacy against E. coli.

収録刊行物

  • 薬学雑誌

    薬学雑誌 69 (6-10), 431-434, 1949

    公益社団法人 日本薬学会

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