The Development of Acute Systemic Multiple Thrombosis after Achieving Remission during Systemic Glucocorticoid Therapy for Acquired Hemophilia A
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- Toyama Kazuhiro
- Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Japan Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan
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- Yasumoto Atsushi
- Department of Clinical Laboratory Medicine, The University of Tokyo Hospital, Japan
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- Nakamura Fumihiko
- Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan
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- Arai Shunya
- Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan
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- Kurokawa Mineo
- Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Japan Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan
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抄録
<p>Acquired hemophilia A (AHA) is a hemorrhagic disorder. Whether or not severe thrombotic events can develop without the use of bypassing agents in AHA patients is unclear. An 80-year-old woman with AHA underwent immunosuppressive therapy with prednisolone at 1 mg/kg daily. After achieving remission, she suddenly developed multiple organ failure due to acute systemic thrombosis and died within a few hours of the diagnosis. Patients with AHA, especially those with risk factors for thrombosis, have a considerable risk of developing thrombosis during the recovery phase of factor VIII activity and should be carefully monitored by coagulation testing. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 57 (15), 2237-2241, 2018-08-01
一般社団法人 日本内科学会