Comparison between ImmunoCAP and multiple antigen simultaneous tests for measuring Aspergillus-specific Immunoglobulin E levels in Aspergillus-sensitized patients

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  • MD, PhD Kuwabara Kazunobu
    Department of Internal Medicine Fujita Health University Banbuntane Houtokukai Hospital
  • MD Yokoi Tatsuyoshi
    Department of Internal Medicine Fujita Health University Banbuntane Houtokukai Hospital
  • MD Yoshida Takazumi
    Department of Internal Medicine Fujita Health University Banbuntane Houtokukai Hospital
  • MD, PhD Shiga Mamoru
    Department of Internal Medicine Fujita Health University Banbuntane Houtokukai Hospital
  • MD, PhD Hirose Masahiro
    Department of Internal Medicine Fujita Health University Banbuntane Houtokukai Hospital
  • MD, PhD Kondo Rieko
    Department of Internal Medicine Fujita Health University Banbuntane Houtokukai Hospital
  • MD, PhD Matsunaga Kayoko
    Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine
  • PhD Nakamura Masashi
    Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine General Research and Development Institute, Hoyu Co., Ltd.
  • MD, PhD Horiguchi Takahiko
    Department of Internal Medicine Fujita Health University Banbuntane Houtokukai Hospital

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  • Comparison between ImmunoCAP and multiple antigen simultaneous tests for measuring <i>Aspergillus</i>-specific Immunoglobulin E levels in <i>Aspergillus</i>-sensitized patients

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<p>Objectives: Aspergillus sensitization is important for patients with asthma. In Japan, the methods applied to measure allergen-specific immunoglobulin E (IgE) levels in blood are the single antigen test, ImmunoCAP (IC), and multiple antigen simultaneous tests, View Allergy® (VA) or MAST IV® (MA). Here, we report the concordance rates (CR) for Aspergillus-specific IgE levels between IC and VA or MA.</p><p>Methods: Aspergillus-specific IgE levels in serum samples from 34 male and 23 female patients with bronchial asthma were measured by ImmunoCAP, View Allergy® (both Thermo Fisher Scientific, Uppsala, Sweden) and MAST IV® (Hitachi Chemical Diagnostics, Inc. Mountain View, CA, USA). Results of Class 1 or greater were regarded as positive, and the CRs between the methods were assessed.</p><p>Results: Of the 57 patients, 24 were found to be positive for Aspergillus-specific IgE by IC, and 5 had allergic bronchopulmonary aspergillosis (ABPA). Significant intraclass correlations were observed between IC and VA (r=0.964, p<0.001) and between IC and MA (r=0.620, p<0.001). Between IC and VA, the CR, positive concordance ratio, and negative concordance ratio was 98.2%, 100%, and 96.9%, respectively; between IC and MA, these values were 77.2%, 45.8%, and 100%, respectively. All five patients with ABPA were found to be positive for Aspergillus-specific IgE by VA, whereas only three of these patients (60%) were found to be positive by MA.</p><p>Conclusions: In patients with asthma, measurements obtained by IC were more concordant with those obtained by VA compared with those obtained by MA.</p>

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