Evaluation of the Impact of Preoperative Values of Hyaluronic Acid and Type IV Collagen on the Outcome of Patients with Hepatocellular Carcinoma After Hepatectomy
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- Ueda Junji
- Department of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School Department of Surgery, Nippon Medical School Tama Nagayama Hospital
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- Yoshida Hiroshi
- Department of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School
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- Mamada Yasuhiro
- Department of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School
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- Taniai Nobuhiko
- Department of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School
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- Yoshioka Masato
- Department of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School
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- Hirakata Atsushi
- Department of Surgery, Nippon Medical School Tama Nagayama Hospital
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- Kawano Youichi
- Department of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School
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- Shimizu Tetsuya
- Department of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School
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- Kanda Tomohiro
- Department of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School
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- Takata Hideyuki
- Department of Surgery, Nippon Medical School Tama Nagayama Hospital
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- Uchida Eiji
- Department of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School
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<p>Background: Recently, some reports have revealed a relationship between post-hepatectomy prognosis in hepatocellular carcinoma (HCC) and hepatic fibrosis markers. We evaluated the relationship between these markers of hepatic fibrosis, clinicopathological findings, and prognosis. Methods: Three hundred and sixty patients underwent hepatectomy for HCC in the Nippon Medical School Hospital between 1993 and 2013. We divided these patients into two groups: normal serum hyaluronic acid (HA) levels and abnormal levels. We also divided patients into groups with normal serum type IV collagen levels and abnormal levels. Results: The overall survival rate and recurrence-free survival rate of the normal group were significantly higher than those of the abnormal group. In the normal hyaluronic acid group, serum albumin and prothrombin time were significantly higher than in the abnormal group, and age, hepatitis C virus antibody (HCV)-Ab positivity, Child-Pugh grade B, liver cirrhosis, indocyanine green retention rate at 15 min (ICGR15), type IV collagen level, and type IV collagen 7s level were significantly lower than those in the abnormal group. In the normal type IV collagen group, HCV-Ab positivity, liver cirrhosis, ICGR15, HA level, and type IV collagen 7s level were significantly lower than those in the abnormal group, and the serum albumin level was significantly higher than that in the abnormal group. Multivariate analysis independently revealed the significant effect of serum type IV collagen on the overall survival rate as well as the significant effect of serum HA on the recurrence-free survival rate in patients who underwent hepatectomy for HCC. Conclusions: Preoperative examinations of serum hyaluronic acid levels and type IV collagen levels are imperative for hepatic resection for HCC because these markers are significantly associated with liver function and prognosis.</p>
収録刊行物
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- 日医大誌
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日医大誌 85 (4), 221-227, 2018-08-15
日本医科大学医学会