Intra-arterial Injection of Fasudil Hydrochloride for Cerebral Vasospasm Secondary to Bacterial Meningitis

DOI Web Site 参考文献16件
  • Nonaka Taku
    Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan
  • Ishikawa Tatsuya
    Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan
  • Yamaguchi Koji
    Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan
  • Yasuda Takayuki
    Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan
  • Omura Yoshihiro
    Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan
  • Oka Mieko
    Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan
  • Kawamata Takakazu
    Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan

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<p>The occurrence of cerebral vasospasm secondary to bacterial meningitis is relatively rare. Furthermore, there is no specific treatment cerebral vasospasm. Endovascular treatment may be essential for cases with the advanced clinical course. Balloon angioplasty or intra-arterial injection of verapamil, nicardipine, or nitroglycerin has been previously reported. We experienced successful treatment using intra-arterial infusion of fasudil hydrochloride. To our knowledge, this is the first case to report the intra-arterial injection of fasudil hydrochloride for treating cerebral vasospasm secondary to bacterial meningitis. A 37-year-old female who presented with dizziness had a right cerebellar tumor that was excised and diagnosed as glioblastoma. On postoperative day 10, Streptococcus oralis meningitis was detected. On postoperative day 20, the patient developed right hemiparesis with a severe vasospasm of the bilateral middle cerebral artery and anterior cerebral artery. Intra-arterial fasudil hydrochloride injection was performed for 3 days, following which the patient’s symptoms improved. Symptomatic cerebral vasospasm secondary to bacterial meningitis is relatively rare and difficult to treat; in selected cases, intra-arterial fasudil hydrochloride injection was an effective treatment for cerebral vasospasm secondary to bacterial meningitis.</p>

収録刊行物

  • NMC Case Report Journal

    NMC Case Report Journal 5 (4), 91-94, 2018

    一般社団法人 日本脳神経外科学会

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