Reduction in Gastroesophageal Reflux Disease Symptoms Is Associated with Miso Soup Intake in a Population-Based Cross-Sectional Study : The Nagahama Study

  • MANO Fumika
    Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University
  • IKEDA Kaori
    Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University
  • SATO Tosiya
    Department of Biostatistics, Kyoto University School of Public Health
  • NAKAYAMA Takeo
    Department of Health Informatics, Kyoto University School of Public Health
  • TANAKA Daisuke
    Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University
  • JOO Erina
    Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University
  • TAKAHASHI Yoshimitsu
    Department of Health Informatics, Kyoto University School of Public Health
  • KOSUGI Shinji
    Department of Medical Ethics/Medical Genetics, Kyoto University School of Public Health
  • SEKINE Akihiro
    Center for Preventive Medical Science, Chiba University
  • TABARA Yasuharu
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine
  • MATSUDA Fumihiko
    Center for Genomic Medicine, Kyoto University Graduate School of Medicine
  • INAGAKI Nobuya
    Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University

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  • Reduction in Gastroesophageal Reflux Disease Symptoms Is Associated with <i>Miso</i> Soup Intake in a Population-Based Cross-Sectional Study: The Nagahama Study

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<p>Dietary habits and lifestyles are considered to affect the frequency of epigastric symptoms. In our previous study, we found that three amino acids in Japanese broth promoted gastric emptying. We hypothesized that a higher consumption of miso soup which was mainly composed of Japanese broth and miso paste would be associated with a lower frequency of epigastric symptoms. We conducted a cross-sectional study of the association between frequency of miso soup intake and reflux or dyspepsia symptoms in a general Japanese population. Sixteen items of dietary habits were assessed using a self-reported questionnaire, and epigastric symptoms were evaluated using the Frequency Scale for Symptoms of Gastroesophageal Reflux Disease (FSSG). We fitted generalized linear models to analyze the association between miso soup intake and FSSG, reflux, or dyspepsia scores adjusted by age, sex, body mass index (BMI), another 15 dietary habits, smoking, drinking alcohol, and unfavorable dietary behaviors. A total of 9,364 subjects were included in the analysis. Trend analysis revealed that higher frequency of miso soup intake was associated with lower FSSG scores (p<0.001). In a generalized linear model, daily intake of miso soup was associated with lower FSSG, reflux, and dyspepsia scores independent of age, sex, BMI, other 15 dietary habits, smoking, drinking alcohol, and unfavorable dietary behaviors (estimate=−0.46, −0.22, and −0.27, respectively; 95% CI=−0.83, −0.12; −0.38, −0.07; and −0.47, and −0.08, respectively). Dairy intake of miso soup was associated with lower epigastric symptoms.</p>

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