A Retrospective Analysis of the Effect of Tigecycline on Coagulation Function

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  • Leng Bing
    Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong University
  • Xue Yuan Chao
    Centre for Heart Lung Innovation, St. Paul’s Hospital and Department of Pathology and Laboratory Medicine, University of British Columbia
  • Zhang Wen
    Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong University
  • Gao Tian tian
    Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong University
  • Yan Gen quan
    Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong University
  • Tang Hui
    Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong University Centre for Heart Lung Innovation, St. Paul’s Hospital and Department of Pathology and Laboratory Medicine, University of British Columbia

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<p>A number of clinical trials demonstrated that tigecycline was effective and well tolerated in the treatment of patients with various bacterial infections, but few literatures had shown the coagulopathy induced by tigecycline. To address this concern, we performed a retrospective analysis to assess the impact of tigecycline treatment on coagulation parameters in 50 patients with bacterial infections in our hospital (Shandong Provincial Hospital, China). These patients were treated with tigecycline at Shandong Provincial Hospital in 2015–2016 at either a recommended (50 mg q12h) or a higher dose (100 mg q12h). Coagulation parameters, including Fibrinogen (FIB) levels, prothrombin time (PT), activated partial thromboplastin time (aPTT), platelet count (PLT) and D-dimer, were evaluated in order to assess the impact of tigecycline treatment in these severely infected patients. What we found was that the plasma fibrinogen (FIB) level was 4.63 ± 1.56 g/L before tigecycline treatment, and decreased to 2.92 ± 1.23 g/L during treatment, which was statistically significant (p < 0.001). The mean values of aPTT and PT were significantly increased from 39.58 ± 8.72 to 44.05 ± 10.45 s (p = 0.002), and from 15.37 ± 1.53 to 16.37 ± 2.64 s (p = 0.004), respectively. This study demonstrates that treatment of tigecycline could reduce FIB, prolong aPTT and PT. In conclusion, we advise that it is necessary for practitioners routinely monitor coagulation level in at-rick patient populations treated with tigecycline.</p>

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