Decreased Wave V Amplitude in Auditory Brainstem Responses of Children with Cerebellar Lesions

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  • Matsuura Yuka
    *Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine, Yonago 683-8503, Japan
  • Oguri Masayoshi
    *Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine, Yonago 683-8503, Japan
  • Saito Yoshiaki
    †Division of Child Neurology, Department of Brain and Neurological Sciences, Tottori University Faculty of Medicine, Yonago 683-8504, Japan
  • Aoe Yasutaka
    *Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine, Yonago 683-8503, Japan
  • Ogawa Ayame
    *Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine, Yonago 683-8503, Japan
  • Akiyama Shota
    *Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine, Yonago 683-8503, Japan
  • Yasuda Nanako
    *Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine, Yonago 683-8503, Japan
  • Sato Kengo
    *Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine, Yonago 683-8503, Japan
  • Maegaki Yoshihiro
    †Division of Child Neurology, Department of Brain and Neurological Sciences, Tottori University Faculty of Medicine, Yonago 683-8504, Japan
  • Hirooka Yasuaki
    *Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine, Yonago 683-8503, Japan

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<p>Background This study aims to elucidate the effect of isolated cerebellar lesions sparing the brainstem on the auditory brainstem responses in children.</p><p>Methods We enrolled 10 children (aged 1–16 years) with cerebellar lesions on neuroimaging but lacking clinical brainstem involvement signs and with normal brainstem volumes on magnetic resonance imaging.</p><p>Results The interpeak latency of waves I and V was normal in 9 patients and was marginally prolonged in 1 patient. While amplitudes of waves I and III were normal, we noted a decreased amplitude of wave V and/or an increased I/V amplitude ratio in 6 patients; these included 5 of 8 patients with cerebellar hypoplasia/atrophy and 1 patient with acute cerebellar ataxia.</p><p>Conclusion Our results support the hypothesis of an inhibitory input from the cerebellar fastigial nucleus on the inferior colliculus, which might be disinhibited because of Purkinje cells dysfunction due to cerebellar cortex lesions, especially within the cerebellar vermis.</p>

収録刊行物

  • Yonago Acta Medica

    Yonago Acta Medica 61 (4), 220-227, 2018

    ヨナゴ・アクタ・メディカ刊行会

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