後天性血友病A患者に対して凝固第Ⅶ因子補充療法を行うも重篤な抜歯後口腔咽頭喉頭血腫を生じた1例

DOI Web Site Web Site 参考文献2件
  • 武田 大介
    神戸大学大学院医学研究科外科系講座口腔外科学分野 独立行政法人地域医療機能推進機構神戸中央病院歯科口腔外科
  • 小松原 秀紀
    神戸大学大学院医学研究科外科系講座口腔外科学分野 独立行政法人地域医療機能推進機構神戸中央病院歯科口腔外科
  • 古森 孝英
    神戸大学大学院医学研究科外科系講座口腔外科学分野

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  • An exceptional case of severe oropharyngolaryngeal hematoma after tooth extraction despite bypass therapy using recombinant activated factor Ⅶ in a patient with acquired hemophilia A
  • コウテンセイ ケツユウビョウ A カンジャ ニ タイシテ ギョウコ ダイ Ⅶ インシ ホジュウ リョウホウ オ オコナウ モ ジュウトク ナ バッシ ゴ コウコウ イントウ コウトウ ケッシュ オ ショウジタ 1レイ

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<p>Bypass therapy using recombinant activated factor Ⅶ (rFⅦa) or activated prothrombin complex concentrate (APCC) is effective for hemostatic treatment in acquired hemophilia A. We report the case of a 78-year-old man who presented with severe oropharyngolaryngeal hematoma after tooth extraction despite using rFⅦa to manage acquired hemophilia A.</p><p>　He was referred to our department because of tenderness of the tongue caused by a metal crown of the left mandibular first molar. About 3 months before our first medical examination, the patient was given a diagnosis of acquired hemophilia A, for which he had subsequently received corticosteroids and had undergone bypass therapy using APCC in the Department of Hematology of our hospital. Panoramic radiography revealed chronic apical periodontitis of the same tooth. We consulted a hematologist. For hemostatic management, rFⅦa preparations were transfused before and after the extraction procedure. However, submucosal hematoma and edema developed in the oral floor the next morning and advanced to the root of the tongue and epiglottis on the following 2 days. We urgently performed intratracheal intubation. After that, rFⅦa preparations were transfused every 3 hours, and the patient was extubated 12 days after tooth extraction.</p>

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