A Novel Animal Model of Induced Breast Precancerous Lesion in Tree Shrew
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- Chen Maojian
- Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University
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- Ou Chao
- Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University
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- Yang Chun
- Department of Experimental Research, The Affiliated Tumor Hospital of Guangxi Medical University
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- Yang Weiping
- Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University
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- Qin Qinghong
- Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University
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- Jiang Wei
- Department of Medical Oncology, The Affiliated Tumor Hospital of Guangxi Medical University
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- Tan Qixing
- Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University
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- Mao Anyun
- Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University
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- Liao Xiaoli
- Department of Medical Oncology, The Affiliated Tumor Hospital of Guangxi Medical University
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- Ye Xinqing
- Department of Pathology, The Affiliated Tumor Hospital of Guangxi Medical University
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- Wei Changyuan
- Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University
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<p>Chinese tree shrew, an animal exhibited closer evolutionary relationship with humans compared to rodents, is getting increasingly attentions as an appealing experimental animal model for human diseases. However, a high-efficiency and stable method to establish tree shrew breast precancerous lesions model has not been clearly elucidated. Thus, the current study aimed to explore the way of establishing breast precancerous model in tree shrew and investigate the pathologic characteristics of induced breast precancerous lesions. The results indicated that 7,12-dimethylbenz(a)anthracene (DMBA) could induce breast lesions in tree shrews. However, comparing to DMBA alone, an addition of medroxyprogesterone acetate (MPA) to DMBA critically increased the rate of induced breast lesion in tree shrews. Half of induced breast lesions were intraductal papilloma and the others were atypical ductal hyperplasia. Induced lesions showed positive expression of estrogen receptor α (ERα), progesterone receptor (PR) and cytokeratin 5/6 (CK5/6), but negative expression of human epidermal growth factor receptor-2 (Her-2). The expression of B cell lymphoma-extra large (Bcl-xl) was significantly higher and the expression of B cell lymphoma 2 associated X protein (Bax) was significantly lower in the precancerous lesions (atypical ductal hyperplasia) compared to benign tumor (intraductal papilloma). These results suggest that DMBA is able to induce breast lesions in tree shrews. Combination of DMBA and MPA may be more effective to establish breast precancerous lesion tree shrew models. Tree shrew might be a promising animal model for studying the tumorogenesis of breast cancer.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 42 (4), 580-585, 2019-04-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390845713074012800
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- NII論文ID
- 130007622065
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 029604037
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- PubMed
- 30674757
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可