A Case of Somatic-Type Malignant Tumor with Isochromosome 12p Arising from a Mature Cystic Teratoma without Genetic Alteration

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  • Nishimaki Haruna
    Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan
  • Nakanishi Yoko
    Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan
  • Nakao Takehiro
    Department of Obstetrics & Gynecology, Nihon University School of Medicine, Nihon University School of Medicine, Tokyo, Japan
  • Takada Shinichi
    Department of Obstetrics & Gynecology, Nihon University School of Medicine, Nihon University School of Medicine, Tokyo, Japan

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  • Case Report : A Case of Somatic-Type Malignant Tumor with Isochromosome 12p Arising from a Mature Cystic Teratoma without Genetic Alteration

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Teratoma is the most common germ cell tumor (GCT) of the ovary. Recently, much has been learned regarding the pathogenesis of GCT from a molecular biology perspective. Based on molecular biological findings, 12p gain, and isochromosome 12p (i(12p)), unlike testicular postpubertal teratoma, most ovarian teratomas are derived from benign germ cells in a parthenogenetic-like process. Furthermore, it is known that somatic-type malignant tumors, such as cancer and sarcoma, rarely arise from dermoid cysts. Herein, we present the case of a patient diagnosed with a malignant neuroepithelial component arising from a mature teratoma. Fluorescence in situ hybridization (FISH) revealed that i(12p) was detected in the malignant component but was absent from the teratomatous portion.

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