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- Kikuta Jun
- Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
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- Saito-Goto Hitomi
- Nihon University Graduate School of Dentistry at Matsudo, Orthodontics, Matsudo, Chiba 271-8587, Japan
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- Iwane Takehiro
- Nihon University Graduate School of Dentistry at Matsudo, Orthodontics, Matsudo, Chiba 271-8587, Japan
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- Shimizu Mami
- Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
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- Hikida Takuji
- Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
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- Nakayama Erika
- Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
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- Kasai Kazutaka
- Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba 271-8587, Japan
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抄録
<p><b>Background </b>Wnt signaling is valuable protein network involved in bone metabolism;however, its relationship in bone resorption and formation during orthodontic treatment is currently unknown.</p><p>Purpose This study examined Wnt5a expression on the compression side in an in vivo experimental rat tooth movement model. The study then investigated the relation of compression force(CF)to Wnt5a expression from human periodontal ligament(PDL)cells.</p><p>Material and Methods In vivo, to movement the maxillary first molar, we added 10 g of orthodontic force to twenty male rats for seven days. We assessed the production of tartrate-resistant acid phosphatase (TRAP) and Wnt5a protein in rats alveolar bone through an immunohistochemical analysis. In vitro, we examined the effect of compression force(CF)on Wnt5a expression using the human PDL(hPDL)cells.</p><p>Results We observed resorption lacunae with the multinuclear cells in rat alveolar bone during tooth movement in the 10g group. We observed Wnt5a immunoreactivity on day seven with orthodontic force in the PDL tissue. Wnt5a expression increased for timedependent maner after addition of CF in hPDL cells.</p><p>Conclusion Given these findings, the Wnt signaling response to optimum orthodontic force appears to stimulate resorption of alveolar bone in the orthodontic tooth movement.</p>
収録刊行物
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- IJOMS
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IJOMS 17 (3-4), 62-68, 2019-03-20
日本大学松戸歯学部 口腔科学研究所
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詳細情報
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- CRID
- 1390001288142391552
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- NII論文ID
- 130007629069
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- ISSN
- 21854254
- 13479733
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- KAKEN
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