Simple Electrocardiographic Score Can Predict Left Ventricular Reverse Remodeling in Patients With Non-Ischemic Cardiomyopathy

• Konishi Shozo

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Ohtani Tomohito

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Mizuno Hiroya

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Sera Fusako

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Nakamoto Kei

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Chimura Misato

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Sengoku Kaoruko

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Miyawaki Hiroshi

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Higuchi Rie

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Kanzaki Machiko

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Tsukamoto Yasumasa

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Hikoso Shungo

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

• Sakata Yasushi

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

抄録

Background: Left ventricular reverse remodeling (LVRR) is a favorable response in non-ischemic, non-valvular cardiomyopathy (NICM) patients. Recently, 18-lead body surface electrocardiography (ECG), the standard 12-lead ECG with synthesized right-sided/posterior chest leads, has been developed, but its predictive value for LVRR has not been evaluated. Methods and Results: Of 216 consecutive hospitalized NICM patients with LV ejection fraction (LVEF) ≤35%, we studied 125 who received optimization of their heart failure treatment and had 18-lead ECG and echocardiography data available for evaluating LVRR, defined as an absolute increase in LVEF ≥10% concomitant with LVEF ≥35% after 1-year optimized treatment. Most 18-lead ECG parameters in the NICM patients differed from those in 312 age- and body mass index-matched subjects with normal echocardiography. LVRR occurred in 59 NICM patients and they had a larger QRS amplitude in the limb leads (I, II, aVR, and aVF), precordial leads (V3–V6), and synthesized leads (syn-V4R–5R), decreased QRS axis and duration, and lower prevalence of fragmented QRS than those without LVRR. The ECG score using 3 selected parameters (QRS amplitude in aVR ≥675 µV; QRS duration <106 ms without fragmentation; and QRS axis <67°) was associated with the incidence of LVRR even after adjusting for optimized treatment. Conclusions: The standard 12-lead ECG parameters are sufficiently predictive of LVRR in NICM patients.

収録刊行物

• Circulation Reports

  Circulation Reports 1 (4), 171-178, 2019-04-10

  一般社団法人 日本循環器学会

キーワード

• Cardiomyopathy
• Electrocardiography
• Reverse remodeling

詳細情報

• CRID: 1390282763108205696
• NII論文ID: 130007630369
• DOI: 10.1253/circrep.cr-19-0005
• ISSN: 24340790
• Web Site: https://www.jstage.jst.go.jp/article/circrep/1/4/1_CR-19-0005/_pdf
• 本文言語コード: en
• データソース種別:
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