Association between vitamin B group supplementation with changes in % flow-mediated dilatation and plasma homocysteine levels: a randomized controlled trial

• Maruyama Koutatsu

  Laboratory of Community Health and Nutrition, Special Course of Food and Health Science, Department of Bioscience, Graduate School of Agriculture, Ehime University

• S. Eshak Ehab

  Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Department of Public Health and Preventive Medicine, Minia University

• Kinuta Minako

  Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine

• Nagao Masanori

  Department of Public Health, Dokkyo Medical University, School of Medicine

• Cui Renzhe

  Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine

• Imano Hironori

  Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine

• Ohira Tetsuya

  Department of Epidemiology, Fukushima Medical University School of Medicine

• Iso Hiroyasu

  Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine

抄録

There is limited evidence examining the association between B vitamin supplementation and improved endothelial function via lowering plasma homocysteine levels. This study investigated whether low-dose B vitamin supplementation improves endothelial dysfunction in Japanese adults with one or more components of metabolic syndrome. A randomized, controlled, crossover trial, without a washout period or blinding of subjects, was conducted from May-September, 2010. The subjects were 127 Japanese men and women aged 40–65 years who had at least one component of metabolic syndrome without medication. Participants took a supplement drink for two months but were divided into early intervention or later intervention groups. The flow-mediated dilatation, plasma homocysteine level, serum B-vitamins, and vitamin C levels were measured. A significant increase in serum B vitamins and vitamin C levels, and a reduction in plasma homocysteine levels were observed. The mean serum homocysteine level pre- and post-intervention was 9.8 and 8.2 µmol/L in the early intervention group and 10.8 and 7.4 µmol/L in the later intervention group (p<0.01). However, no significant changes in flow-mediated dilatation was found. Low-dose multivitamin supplementation including B vitamins is associated with a significant reduction in plasma homocysteine levels among patients with one or more components of metabolic syndrome. This study was registered at the University Hospital Medical Information Network (UMIN) centre, and has the identifier UMIN000004436.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 64 (3), 243-249, 2019

  一般社団法人　日本酸化ストレス学会

キーワード

• folate
• vitamin B6
• vitamin B12
• plasma homocysteine
• clinical trial

詳細情報

• CRID: 1390845713065444992
• NII論文ID: 130007641471
• DOI: 10.3164/jcbn.17-56
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://www.jstage.jst.go.jp/article/jcbn/64/3/64_17-56/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020032227
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可