Telomerase Inhibition, Telomere Shortening, and Cellular Uptake of the Perylene Derivatives PM2 and PIPER in Prostate Cancer Cells
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- Kaewtunjai Navakoon
- Department of Biochemistry, Faculty of Medicine, Chiang Mai University
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- Summart Ratasark
- Department of Biochemistry, Faculty of Medicine, Chiang Mai University
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- Wongnoppavich Ariyaphong
- Department of Biochemistry, Faculty of Medicine, Chiang Mai University
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- Lojanapiwat Bannakij
- Department of Surgery, Faculty of Medicine, Chiang Mai University
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- Lee T. Randall
- Department of Chemistry and the Texas Center for Superconductivity, University of Houston
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- Tuntiwechapikul Wirote
- Department of Biochemistry, Faculty of Medicine, Chiang Mai University
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<p>Prostate cancer is the second most common cancer among men worldwide, and it is ranked first in the United States and Europe. Since prostate cancer is slow-growing, active surveillance for low-risk cancer has been increasingly supported by various guidelines. Most prostate cancers reactivate telomerase to circumvent the replicative senescence caused by the end replication problem; therefore, telomerase inhibition is potentially useful for the suppression of prostate cancer progression during this active surveillance or for the prevention of cancer recurrence after conventional therapies. In this study, we demonstrated that the perylene derivatives, PM2 and PIPER, could suppress human telomerase reverse transcriptase (hTERT) expression and telomerase activity in the short-term treatment of androgen-dependent prostate cancer cell line LNCaP and the androgen-independent prostate cancer cell line PC3 prostate cancer cells. Long-term treatment with subcytotoxic doses of these compounds in both prostate cancer cells showed telomere shortening and a significant increase in senescent cells. Although the acute cytotoxicity of PM2 was about 30 times higher than that of PIPER in both prostate cancer cells, the cellular uptake of both compounds was comparable as determined by flow cytometry and fluorescent microscopy.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 42 (6), 906-914, 2019-06-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390564238096479232
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- NII論文ID
- 130007657664
- 40021899771
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 029698332
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- PubMed
- 30930403
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可