ATP-dependent potassium channels contribute to motor regulation of esophageal striated muscle in rats
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- HORII Kazuhiro
- Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagaido, Gifu 501-1193, Japan
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- SUZUKI Yuji
- Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagaido, Gifu 501-1193, Japan
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- SHIINA Takahiko
- Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagaido, Gifu 501-1193, Japan
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- SAITO Shouichiro
- Department of Basic Veterinary Science, Laboratory of Anatomy, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagaido, Gifu 501-1193, Japan
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- ONOUCHI Sawa
- Department of Basic Veterinary Science, Laboratory of Anatomy, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagaido, Gifu 501-1193, Japan
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- HORII Yuuki
- Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagaido, Gifu 501-1193, Japan
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- SHIMAOKA Hiroki
- Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagaido, Gifu 501-1193, Japan
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- SHIMIZU Yasutake
- Department of Basic Veterinary Science, Laboratory of Physiology, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagaido, Gifu 501-1193, Japan Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN), Gifu University, 1-1 Yanagaido, Gifu 501-1193, Japan
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抄録
<p>The aim of the present study was to clarify roles of ATP-dependent potassium channels (KATP channels) in motility of the striated muscle portion in the esophagus. An isolated segment of the rat esophagus was placed in an organ bath and mechanical responses were recorded using a force transducer. Electrical stimulation of the vagus nerve evoked contractile response of striated muscle in the esophageal segment. Application of glibenclamide, an antagonist of KATP channels, increased amplitude of vagally mediated twitch contractions of the rat esophagus. On the other hand, minoxidil, an agonist of KATP channels, decreased amplitude of twitch contractions. RT-PCR revealed the expression of subunits of KATP channels in esophageal tissue. In addition, immunopositivity for subunits of KATP channels was observed in the striated muscle cells of the esophageal muscle layer. These findings indicate that KATP channels contribute to motor regulation of striated muscle in the rat esophagus.</p>
収録刊行物
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- Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ
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Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ 81 (9), 1266-1272, 2019
公益社団法人 日本獣医学会