The Bacteriological Properties of <i>Bacillus</i> Strain TM-I-3 and Analysis of the Volatile Antifungal Compounds Emitted by this Bacteria
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- OSAKI CHIHIRO
- Faculty of Pharmaceutical Sciences, Nagasaki International University
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- YAMAGUCHI KYOSHIRO
- Faculty of Pharmaceutical Sciences, Nagasaki International University
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- URAKAWA SHINJI
- T. M Enterprise
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- NAKASHIMA YUKIHIKO
- Pharmaceutical Sciences, Fukuoka University
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- SUGITA KAZUTOSHI
- Faculty of Veterinary, Azabu University
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- NAGAISHI MASAKI
- Ceramic Research Center of Nagasaki
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- MITSUIKI SHINJI
- Department of Applied Chemistry and Biochemistry, Kyusyu Sangyo University
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- KURAOKA TAKUYA
- Faculty of Pharmaceutical Sciences, Nagasaki International University
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- OGAWA YUKIKO
- Faculty of Pharmaceutical Sciences, Nagasaki International University
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- SATO HIROSHI
- Faculty of Pharmaceutical Sciences, Nagasaki International University
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抄録
<p>Previously, we isolated and examined a bacterial strain designated as TM-I-3, belonging to the genus Bacillus, from soil in Nagasaki, Japan. This bacterium was able to inhibit the growth of molds, without coming into direct contact with them. Non-contact antifungals are capable of providing multidirectional inhibition and may contribute to disease prevention. In this study, we revealed the bacteriological properties of TM-I-3 and evaluated the antifungal activity of the compounds emitted from this bacterium. In addition, we analyzed the antimicrobial substances released from TM-I-3 using GC/MS to elucidate the mechanism of its action. Antimicrobial compounds from strain TM-I-3 were identified as acetic acid, propanoic acid, isovaleric acid, 2-methylbutanoic acid, and benzaldehyde, which are all reported to have antimicrobial activity. TM-I-3 demonstrated possible efficacy in inhibiting the growth of Aspergillus fumigatus, Cladosporium cladosporioides and Penicillium expansum, which may lead to inhibition of common fungal contaminants of household products and prevention of some pulmonary diseases.</p>
収録刊行物
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- Ｂｉｏｃｏｎｔｒｏｌ Ｓｃｉｅｎｃｅ
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Ｂｉｏｃｏｎｔｒｏｌ Ｓｃｉｅｎｃｅ 24 (3), 129-136, 2019
日本防菌防黴学会