膀胱求心性神経の薬理学的機能解析

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  • 相澤 直樹
    東京大・院医・コンチネンス医学（寄附講座）
  • 井川 靖彦
    東京大・院医・コンチネンス医学（寄附講座）

書誌事項

タイトル別名
  • Afferent Nerve Activity in Relation to Bladder Sensation
  • ボウコウ キュウシンセイ シンケイ ノ ヤクリガクテキ キノウ カイセキ

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<p>Bladder afferent nerves are composed by myelinated Aδ- and unmyelinated C-fibers. During the storage phase of urine, distention of the bladder has long been considered to evoke afferent activity via Aδ-fibers connected in series with the smooth muscle fibers. In contrast, a previous study in cats revealed that more than 90% of C-fibers do not respond to normal bladder distension, being so called "silent" fibers. However, at least in rats, C-fibers can respond to normal bladder distension like Aδ-fibers, although they may also fulfill a potentially different role in the bladder sensory function in response to abnormal stimuli.</p><p>The symptoms of overactive bladder (OAB) or interstitial cystitis (IC) are believed to be commonly related to the sensory (afferent) function. In our laboratory, a direct measuring technique of mechanosensitive single-unit afferent activities of the primary bladder nerves in the rat has been established, and we have investigated the direct effects of drugs (anticholinergics, β3-adrenoceptor agonists, α1-adrenoceptor antagonists, PDE type5 inhibitors, etc.) on the bladder afferent function.</p><p>In this symposium, we will show some of our results and propose a possible additional action on sensory pathway of drugs as therapeutic agents for OAB or IC.</p>

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