Role of MafB in macrophages

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  • Hamada Michito
    Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan Laboratory Animal Resource Center (LARC), Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
  • Tsunakawa Yuki
    Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
  • Jeon Hyojung
    Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan Laboratory Animal Resource Center (LARC), Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
  • Yadav Manoj Kumar
    Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan
  • Takahashi Satoru
    Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan Laboratory Animal Resource Center (LARC), Faculty of Medicine, University of Tsukuba, 1–1-1 Tennodai, Tsukuba, Ibaraki 305–8575, Japan

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Abstract

<p>The transcription factor MafB regulates macrophage differentiation. However, studies on the phenotype of Mafb-deficient macrophages are still limited. Recently, it was shown that the specific expression of MafB permits macrophages to be distinguished from dendritic cells. In addition, MafB has been reported to be involved in various diseases related to macrophages. Studies using macrophage-specific Mafb-deficient mice show that MafB is linked to atherosclerosis, autoimmunity, obesity, and ischemic stroke, all of which exhibit macrophage abnormality. Therefore, MafB is hypothesized to be indispensable for the regulation of macrophages to maintain systemic homeostasis and may serve as an innovative target for treating macrophage-related diseases.</p>

Journal

  • Experimental Animals

    Experimental Animals 69 (1), 1-10, 2020

    Japanese Association for Laboratory Animal Science

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