中鎖脂肪の摂取がラットの脂質代謝や小腸二糖類水解酵素活性に及ぼす影響

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  • Effects of Medium Chain Triglycerides Intake on Lipid Metabolism and Intestinal Disaccharidase Activities in Rats
  • チュウ サ シボウ ノ セッシュ ガ ラット ノ シシツ タイシャ ヤ ショウチョウ ニ トウルイ スイカイ コウソ カッセイ ニ オヨボス エイキョウ

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<p>It has been reported that medium-chain triglyceride (MCT) have various physiological functions, such as anti-obesity and hypolipidemic effects. They can also elicit increased disaccharidase activity and intestinal cell proliferation. However, a meta-analysis of randomized controlled trials, comparing the effects of MCT on weight loss and body composition, detected commercial bias. Additional research on the physiological functions is needed in order to have conclusive evidence. Thus, we sought to evaluate the various functions of MCT by conducting a feeding study in rats. Rats fed a diet containing 15% (w/w) MCT, had significantly lower visceral fat weight, plasma and liver lipid concentrations; they had significantly higher intestinal maltase and glucoamylase activities; and they had a greater number of Ki-67 positive cells/crypt, compared to the rats fed a diet containing 15% (w/w) lard. The effects of a diet containing 5% (w/w) MCT was observed only for plasma cholesterol levels and the number of Ki-67 positive cells/crypt; in which some results were found to be inconsistent with previous reports. These results indicate that physiological functions of MCT are numerous and need to be confirmed by additional research.</p>

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  • 薬学雑誌

    薬学雑誌 140 (8), 1051-1061, 2020-08-01

    公益社団法人 日本薬学会

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