Moderate Levels of N-Terminal Pro-B-Type Natriuretic Peptide is Associated with Increased Risks of Total and Ischemic Strokes among Japanese: The Circulatory Risk in Communities Study

• Ebihara Kenji

  Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba

• Yamagishi Kazumasa

  Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba Osaka Center for Cancer and Cardiovascular Disease Prevention Ibaraki Western Medical Center

• Umesawa Mitsumasa

  Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba Osaka Center for Cancer and Cardiovascular Disease Prevention Department of Public Health, Dokkyo Medical University School of Medicine

• Muraki Isao

  Osaka Center for Cancer and Cardiovascular Disease Prevention Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine

• Cui Renzhe

  Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine

• Imano Hironori

  Osaka Center for Cancer and Cardiovascular Disease Prevention Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine

• Kubota Yasuhiko

  Osaka Center for Cancer and Cardiovascular Disease Prevention

• Hayama-Terada Mina

  Osaka Center for Cancer and Cardiovascular Disease Prevention Yao Public Health Center, Yao City Office

• Shimizu Yuji

  Osaka Center for Cancer and Cardiovascular Disease Prevention

• Ohira Tetsuya

  Department of Epidemiology, Fukushima Medical University School of Medicine

• Sankai Tomoko

  Department of Public Health and Nursing, Faculty of Medicine, University of Tsukuba

• Okada Takeo

  Osaka Center for Cancer and Cardiovascular Disease Prevention

• Kitamura Akihiko

  Osaka Center for Cancer and Cardiovascular Disease Prevention Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology

• Kiyama Masahiko

  Osaka Center for Cancer and Cardiovascular Disease Prevention

• Iso Hiroyasu

  Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine

• for the CIRCS Investigators

抄録

Aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP), frequently used as a biochemical marker for detecting and monitoring heart failure, is also a risk marker for development of coronary heart disease and total stroke. However, studies that explore subtypes of ischemic stroke with regard to NT-proBNP are scarce. Here, we examined NT-proBNP and its impact upon subtypes of ischemic stroke (lacunar stroke, large-artery occlusive stroke and embolic stroke) among Japanese. Methods: We measured NT-proBNP and categorized 4,393 participants of the Circulatory Risk in Communities Study into four groups (＜55, 55-124, 125-399, and ≥ 400 pg/ml). We used a multivariable Cox proportional hazards model to examine association with risks of stroke and subtypes. Results: During 4.7 years of follow-up, we identified 50 strokes, including 35 ischemic (15 lacunar, 6 largeartery occlusive, 10 embolic strokes) and 14 hemorrhagic strokes. NT-proBNP was associated with stroke risk: the multivariable hazard ratio of total strokes was 7.29 (2.82-18.9) for the highest and 2.78 (1.25-6.16) for the second highest NT-proBNP groups compared with the lowest group. The respective hazard ratios for the highest NT-proBNP group were 9.37 (3.14–28.0) for ischemic stroke and 6.81 (1.11–41.7) for lacunar stroke. Further adjustment for atrial fibrillation did not attenuate these associations. The associations were similarly observed for large-artery occlusive and embolic strokes. Conclusion: We found that even moderate serum levels of NT-proBNP were associated with the risk of total and ischemic strokes among Japanese whose NT-proBNP levels were relatively low compared with Westerners.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 27 (8), 751-760, 2020-08-01

  一般社団法人 日本動脈硬化学会

キーワード

• Follow-up study
• Epidemiology
• Biomarker
• Risk factor

詳細情報

• CRID: 1390566775156846208
• NII論文ID: 130007883648
• NII書誌ID: AA11018976
• DOI: 10.5551/jat.52241
• ISSN: 18803873
• ISSN: 13403478
• HANDLE: 2241/00160687
• PubMed: 31932552
• Web Site: https://tsukuba.repo.nii.ac.jp/records/55286
• Web Site: https://www.jstage.jst.go.jp/article/jat/27/8/27_52241/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2021088777
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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