Factors Associated With Elevated N-Terminal Pro B-Type Natriuretic Peptide Concentrations at the Convalescent Stage and 1-Year Outcomes in Patients With Heart Failure With Preserved Ejection Fraction
-
- Oeun Bolrathanak
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
- Nakatani Daisaku
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
- Hikoso Shungo
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
- Kojima Takayuki
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
- Dohi Tomoharu
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
- Kitamura Tetsuhisa
- Department of Environmental Medicine and Population Sciences, Osaka University Graduate School of Medicine
-
- Okada Katsuki
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
- Sunaga Akihiro
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
- Kida Hirota
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
- Yamada Takahisa
- Division of Cardiology, Osaka General Medical Center
-
- Uematsu Masaaki
- Division of Cardiology, National Hospital Organization, Osaka National Hospital
-
- Yasumura Yoshio
- Division of Cardiology, Amagasaki Chuo Hospital
-
- Higuchi Yoshiharu
- Division of Cardiology, Osaka Police Hospital
-
- Mano Toshiaki
- Division of Cardiology, Kansai Rosai Hospital
-
- Nagai Yoshiyuki
- Division of Cardiology, Rinku General Medical Center
-
- Fuji Hisakazu
- Division of Cardiology, Kobe Ekisaikai Hospital
-
- Mizuno Hiroya
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
-
- Sakata Yasushi
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
この論文をさがす
抄録
<p>Background:Little is known about factors associated with elevated N-terminal pro B-type natriuretic peptide (NT-proBNP) at the convalescent stage and their effects on 1-year outcomes in patients with heart failure with preserved ejection fraction (HFpEF).</p><p>Methods and Results:This study included 469 patients with HFpEF. Elevated NT-proBNP was defined as the highest quartile. The first 3 quartiles (Q1–Q3) were combined together for comparison with the fourth quartile (Q4). Median NT-proBNP concentrations in Q1–Q3 and Q4 were 669 and 3,504 pg/mL, respectively. Multivariate logistic regression analysis revealed that low albumin (odds ratio [OR] 2.44; 95% confidence interval [CI] 1.35–4.39; P=0.003), low estimated glomerular filtration rate (OR 5.83; 95% CI 3.46–9.83; P<0.001), high C-reactive protein (OR 2.09; 95% CI 1.21–3.63; P=0.009), and atrial fibrillation at discharge (OR 2.33; 95% CI 1.40–3.89; P=0.001) were associated with elevated NT-proBNP. Cumulative rates of all-cause mortality and heart failure rehospitalization were significantly higher in Q4 than in Q1–Q3 (P=0.001 and P<0.001, respectively). Incidence and hazard ratios of these adverse events increased when the number of associated factors for elevated NT-proBNP clustered together (P<0.001 and P=0.002, respectively).</p><p>Conclusions:In addition to atrial fibrillation, extracardiac factors (malnutrition, renal impairment and inflammation) were associated with elevated NT-proBNP at the convalescent stage, and led to poor prognosis in patients with HFpEF.</p>
収録刊行物
-
- Circulation Reports
-
Circulation Reports 2 (8), 400-408, 2020-08-07
一般社団法人 日本循環器学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390285300181369856
-
- NII論文ID
- 130007885731
-
- ISSN
- 24340790
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可