Immunotoxicity in the placenta: The role of inflammasome on pregnancy complications

• SHIRASUNA Koumei

  Tokyo University of Agriculture

Bibliographic Information

Other Title

• 胎盤における免疫毒性：妊娠異常におけるインフラマソームの役割

Abstract

Reproduction involves tightly regulated series of events and the immune system is involved in an array of reproductive processes. Disruption of well-controlled immune functions leads to placental inflammation and dysfunction, resulting in various pregnancy complications, including preeclampsia (PE). Inflammasomes are involved in the process of pathogen clearance and sterile inflammation. They are large multi-protein complexes that are located in the cytosol and play key roles in the production of the pivotal inflammatory cytokines, interleukin (IL)-1β. The NLRP3 inflammasome is a key mediator of sterile inflammation induced by various types of damage-associated molecular patterns (DAMPs). Recent evidence indicates that the NLRP3 inflammasome is involved in pregnancy dysfunction, including PE. Many DAMPs (uric acid, palmitic acid, high-mobility group box 1, advanced glycation end products, extracellular vesicles, cell-free DNA, and free fatty acids) are increased and associated with pregnancy complications, especially PE. This presentation will focus on the role of the NLRP3 inflammasome in the pathophysiology of PE.

Journal

• Annual Meeting of the Japanese Society of Toxicology

  Annual Meeting of the Japanese Society of Toxicology 47.1 (0), S16-3-, 2020

  The Japanese Society of Toxicology

Details

• CRID: 1390567172568456704
• NII Article ID: 130007898497
• DOI: 10.14869/toxpt.47.1.0_s16-3
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed