Slowly Progressive Male Alport Syndrome Evaluated by Serial Biopsy: Importance of Type IV Collagen Staining
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- Sato Masayo
- Department of Nephrology, Tokyo Women's Medical University, Japan
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- Manabe Shun
- Department of Nephrology, Tokyo Women's Medical University, Japan
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- Itabashi Mitsuyo
- Department of Nephrology, Tokyo Women's Medical University, Japan
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- Horita Shigeru
- Department of Clinical Laboratory Medicine, Tokyo Women's Medical University Hospital, Japan
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- Hirose Orie
- Department of Pathology, Tokyo Women's Medical University, Japan
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- Kawashima Moe
- Department of Nephrology, Tokyo Women's Medical University, Japan
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- Nishida Miki
- Department of Nephrology, Tokyo Women's Medical University, Japan
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- Kataoka Hiroshi
- Department of Nephrology, Tokyo Women's Medical University, Japan Clinical Research Division for Polycystic Kidney Disease, Department of Medicine, Kidney Center, Tokyo Women's Medical University, Japan
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- Taneda Sekiko
- Department of Pathology, Tokyo Women's Medical University, Japan
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- Mochizuki Toshio
- Department of Nephrology, Tokyo Women's Medical University, Japan Clinical Research Division for Polycystic Kidney Disease, Department of Medicine, Kidney Center, Tokyo Women's Medical University, Japan
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- Nitta Kosaku
- Department of Nephrology, Tokyo Women's Medical University, Japan
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抄録
<p>A slowly progressive middle-aged man initially diagnosed with thin basement membrane nephropathy based on extensive thinning of the glomerular basement membrane (GBM) was subsequently diagnosed with Alport syndrome (AS) by a serial renal biopsy eight years later. The ultrastructural analysis of the second biopsy indicated thickening and wrinkling with mild reticulation in the GBM, consistent with AS. However, a retrospective analysis of the first biopsy revealed mild attenuation of type IV collagen α5 chain staining, suggesting a potential diagnosis of AS, despite the lack of ultrastructural features of AS. We herein report the clinical usefulness of type IV collagen staining in the early diagnosis of AS. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 61 (8), 1205-1209, 2022-04-15
一般社団法人 日本内科学会
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詳細情報
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- CRID
- 1390854717938613760
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- NII論文ID
- 130008103229
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- ISSN
- 13497235
- 09182918
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- PubMed
- 34645753
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可