Slowly Progressive Male Alport Syndrome Evaluated by Serial Biopsy: Importance of Type IV Collagen Staining

  • Sato Masayo
    Department of Nephrology, Tokyo Women's Medical University, Japan
  • Manabe Shun
    Department of Nephrology, Tokyo Women's Medical University, Japan
  • Itabashi Mitsuyo
    Department of Nephrology, Tokyo Women's Medical University, Japan
  • Horita Shigeru
    Department of Clinical Laboratory Medicine, Tokyo Women's Medical University Hospital, Japan
  • Hirose Orie
    Department of Pathology, Tokyo Women's Medical University, Japan
  • Kawashima Moe
    Department of Nephrology, Tokyo Women's Medical University, Japan
  • Nishida Miki
    Department of Nephrology, Tokyo Women's Medical University, Japan
  • Kataoka Hiroshi
    Department of Nephrology, Tokyo Women's Medical University, Japan Clinical Research Division for Polycystic Kidney Disease, Department of Medicine, Kidney Center, Tokyo Women's Medical University, Japan
  • Taneda Sekiko
    Department of Pathology, Tokyo Women's Medical University, Japan
  • Mochizuki Toshio
    Department of Nephrology, Tokyo Women's Medical University, Japan Clinical Research Division for Polycystic Kidney Disease, Department of Medicine, Kidney Center, Tokyo Women's Medical University, Japan
  • Nitta Kosaku
    Department of Nephrology, Tokyo Women's Medical University, Japan

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抄録

<p>A slowly progressive middle-aged man initially diagnosed with thin basement membrane nephropathy based on extensive thinning of the glomerular basement membrane (GBM) was subsequently diagnosed with Alport syndrome (AS) by a serial renal biopsy eight years later. The ultrastructural analysis of the second biopsy indicated thickening and wrinkling with mild reticulation in the GBM, consistent with AS. However, a retrospective analysis of the first biopsy revealed mild attenuation of type IV collagen α5 chain staining, suggesting a potential diagnosis of AS, despite the lack of ultrastructural features of AS. We herein report the clinical usefulness of type IV collagen staining in the early diagnosis of AS. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 61 (8), 1205-1209, 2022-04-15

    一般社団法人 日本内科学会

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