αvβ3 integrin-dependent endothelial cell dynamics in vivo

• Paul A. Rupp

  Department of Anatomy and Cell Biology, University of Kansas Medical Center,3901 Rainbow Boulevard, Kansas City, KS 66160, USA

• András Czirók

  Department of Anatomy and Cell Biology, University of Kansas Medical Center,3901 Rainbow Boulevard, Kansas City, KS 66160, USA

• Charles D. Little

  Department of Anatomy and Cell Biology, University of Kansas Medical Center,3901 Rainbow Boulevard, Kansas City, KS 66160, USA

抄録

A major challenge confronting developmental cell biologists is to understand how individual cell behaviors lead to global tissue organization. Taking advantage of an endothelial cell-specific marker and scanning time-lapse microscopy, we have examined the formation of the primary vascular pattern during avian vasculogenesis. Five types of distinguishable endothelial cell motion are observed during formation of a vascular plexus: (1) global tissue deformations that passively convect endothelial cells; (2) vascular drift, a sheet-like medial translocation of the entire vascular plexus; (3)structural rearrangements, such as vascular fusion; (4) individual cell migration along existing endothelial structures; and (5) cell process extension into avascular areas, resulting in new links within the plexus. The last four types of motion are quantified and found to be reduced in the presence of an αvβ3 integrin inhibitor. These dynamic cell motility data result in new hypotheses regarding primordial endothelial cell behavior during embryonic vasculogenesis.

収録刊行物

• Development

  Development 131 (12), 2887-2897, 2004-06-15

  The Company of Biologists

キーワード

• Developmental Biology
• Molecular Biology

詳細情報

• CRID: 1360011144060776320
• NII論文ID: 30002333505
• DOI: 10.1242/dev.01160
• ISSN: 14779129
• ISSN: 09501991
• Web Site: http://journals.biologists.com/dev/article-pdf/131/12/2887/1505205/2887.pdf
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