Vasopressin phosphorylates HSP27 in aortic smooth muscle cells

• Shigeru Akamatsu

• Keiichi Nakajima

• Akira Ishisaki

• Hiroyuki Matsuno

• Kumiko Tanabe

• Mariko Takei

• Motoki Takenaka

• Kouseki Hirade

• Naoki Yoshimi

• Hidetaka Suga

• Yutaka Oiso

• Kanefusa Kato

• Osamu Kozawa

抄録

Administration of arginine vasopressin (AVP) time‐dependently induced the phosphorylation of heat shock protein 27 (HSP27) at Ser‐15 and Ser‐85 in smooth muscle of aorta in vivo. The AVP‐induced phosphorylation of HSP27 at Ser‐15 and Ser‐85 was inhibited by a V1a receptor antagonist but not by a V2 receptor antagonist. In cultured aortic smooth muscle A10 cells, AVP markedly stimulated the phosphorylation of HSP27 at Ser‐15 and Ser‐85. The AVP‐induced phosphorylation of HSP27 was attenuated by SB203580 and PD169316, inhibitors of p38 mitogen‐activated protein (MAP) kinase, but not by PD98059, a MEK inhibitor. These results strongly suggest that AVP phosphorylates HSP27 via p38 MAP kinase in aortic smooth muscle cells. © 2004 Wiley‐Liss, Inc.

収録刊行物

• Journal of Cellular Biochemistry

  Journal of Cellular Biochemistry 92 (6), 1203-1211, 2004-06-14

  Wiley

キーワード

• Cell Biology
• Molecular Biology
• Biochemistry

詳細情報

• CRID: 1360855571371652480
• NII論文ID: 30003488366
• DOI: 10.1002/jcb.20148
• ISSN: 10974644
• ISSN: 07302312
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjcb.20148
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcb.20148
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