Association of IgG anti‐GD<sub>1a</sub> antibody with severe Guillain–Barré syndrome

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<jats:title>Abstract</jats:title><jats:p>We earlier reported cases of 2 patients with severe acute Guillain–Barré syndrome (GBS) associated with high‐IgG anti‐GD<jats:sub>1a</jats:sub> antibody titer. We now have investigated the autoantibody against GD<jats:sub>1a</jats:sub> or GM<jats:sub>1</jats:sub> in 37 GBS patients using the enzyme‐linked immunosorbent assay and have found a statistically significant association between IgG anti‐GD<jats:sub>1a</jats:sub> antibody and the severity of the disease (need of a respiratory for more than 1 month and a poor functional prognosis 3 months after neurologic onset). An autopsy which showed severe GBS associated with IgG anti‐GD<jats:sub>1a</jats:sub> antibody produced the following findings: (1) severe axonal degeneration and segmental demyelination of peripheral nerves; (2) lymphocytic infiltration; and (3) marked central chromatolysis of the lower motoneurons. © 1993 John Wiley & Sons, Inc.</jats:p>

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