New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline

DOI Web Site Web Site 被引用文献6件

抄録

<jats:title>Summary</jats:title><jats:p><jats:bold>Background</jats:bold> : In functional gastrointestinal (GI) disorders including functional dyspepsia (FD) and irritable bowel syndrome (IBS), there might be no small extent of contributions of psychosomatic factors. As a therapy for IBS patients, the effectiveness of antidepressants has been reported.</jats:p><jats:p><jats:bold>Aim</jats:bold> : In this study, we evaluated the efficacy of H<jats:sub>2</jats:sub>‐receptor antagonist (famotidine) and 5‐HT<jats:sub>4</jats:sub> receptor agonist (mosapride citrate). In addition, the effect of antidepressants was assessed as the second‐step therapy.</jats:p><jats:p><jats:bold>Methods</jats:bold> : Patients complaining upper GI symptoms were diagnosed as FD excluding organic diseases. Randomized patients received 20 mg/day of famotidine or 15 mg/day of mosapride citrate for 4 weeks and the efficacy was compared between the two groups based on a 10‐point visual analogue scale. When symptoms were not relieved (score improvement 0–2 points), patients received amitriptyline (30 mg/day) or no medication for 4 weeks randomly. Patients who had depression in psychological test (SDS) were omitted.</jats:p><jats:p><jats:bold>Results</jats:bold> : As the first‐step therapy, both famotidine and mosapride showed beneficial effects regardless of FD subtypes, age and gender. The efficacy of these two drugs in relieving FD symptoms was not significantly different. In patients who failed in the first‐step therapy, amitriptyline showed beneficial effects.</jats:p><jats:p><jats:bold>Conclusions</jats:bold> : These findings might be clinically important in view of the efficient relief of symptoms in FD patients.</jats:p>

収録刊行物

被引用文献 (6)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ