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- Tsuruma Akinori
- Graduate School of Science, Hokkaido University, Japan
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- Tanaka Masaru
- Creative Research Initiative 'Sousei', Hokkaido University, Japan PRESTO, CREST, JST, Japan
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- Fukushima Nobuyuki
- Graduate School of Medicine, Hokkaido University, Japan
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- Shimomura Masatsugu
- Nanotechnology Research Center, Hokkaido University , Japan CREST, JST, Japan
抄録
In tissue engineering, micro/nanofabrication is important to modify substrate surfaces for regulating the attachment and growth of cells. In neuroscience, it is significant for neural regeneration; this involves guiding and extending dendrites and axons by a cell culture scaffold which acts as an extra cellular matrix. In this study, we prepared highly regular porous honeycomb-patterned films by a simple casting technique and cultured neurons to investigate their morphologies on the patterned films. The morphologies of neurons were examined by a scanning electron microscope and a confocal laser scanning microscope. The neurons were round and the neurites extended randomly on the flat film. The patterns influenced the morphologies of neurons. The morphologies of neurons were changed by varying the pore size of the honeycomb- patterned films. The neurites spread along the rims of the honeycomb pattern. These results suggest that the self-organized honeycomb-patterned films are useful biomaterials for neural tissue engineering. [DOI: 10.1380/ejssnt.2005.159]
収録刊行物
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- e-Journal of Surface Science and Nanotechnology
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e-Journal of Surface Science and Nanotechnology 3 159-164, 2005
公益社団法人 日本表面真空学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282680163587712
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- NII論文ID
- 130004438941
- 30006882168
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- ISSN
- 13480391
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可