Detection of Exercise‐Induced Myocardial Ischemia by Multichannel Magnetocardiography in Single Vessel Coronary Artery Disease

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<jats:p><jats:bold>Background: </jats:bold> Detection of myocardial ischemia was studied with multichannel exercise magneto‐cardiography (MCG). A surface gradient method was applied to analyze cardiac magnetic fields.</jats:p><jats:p><jats:bold>Methods: </jats:bold> We studied 27 patients with single vessel coronary artery disease (CAD) and 17 healthy volunteers. The MCG was recorded over anterior chest during supine bicycle ergometry. The two‐dimensional direction of the maximum spatial magnetic field gradient was determined during the ST segment and at the T‐wave apex at different phases of stress test.</jats:p><jats:p><jats:bold>Results: </jats:bold> The CAD patient group was separated from controls by the orientation of the magnetic field gradient during the ST segment at cessation of exercise (CAD 167 ± 68° vs controls 106 ± 49°; P < 0.005) and at 4 minutes postexercise, but not at rest. The‐CAD patient group was separated from controls also by the orientation of the magnetic field gradient at the T‐wave apex at 4 minutes postexercise (CAD 87 ± 60° vs controls 58 ± 18° P < 0.05), but not at rest. The change in the orientation of the field gradient at the T‐wave apex 4 minutes postexercise, compared to baseline, was greater in CAD patients (31 ± 43°) than in controls (9 ± 8° P < 0.05). This change was larger in the patient group with stenosis in the right than in the left coronary artery (P < 0.05).</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> Transient acute myocardial ischemia causes well‐recognizable changes in the magnetocardiogram at the ST segment and the T wave. The orientation of the maximum spatial gradient of the magnetic field can be used as a parameter to determine these changes.</jats:p>

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