Upregulation of striatal adenosine A_2A receptor mRNA in 6‐hydroxydopamine‐lesioned rats intermittently treated with L‐DOPA

• Masahiko Tomiyama

• Tamaki Kimura

• Tetsuya Maeda

• Hiroyasu Tanaka

• Kazuya Kannari

• Masayuki Baba

抄録

To determine whether the adenosine A 2A receptor might play a role in L‐DOPA‐induced dyskinesia in Parkinson's disease, we analyzed changes in the expression of A 2A receptor mRNA in response to intermittent treatment with L‐DOPA in rats with dopaminergic denervation by 6‐hydroxydopamine (OHDA) infusion into the medial forebrain bundle. Intermittent treatment with L‐DOPA increased A 2A receptor mRNA levels in the dopamine‐depleted striatum of 6‐OHDA‐lesioned rats exhibiting behavioral sensitization to L‐DOPA. These results suggest that A 2A receptor activation is associated with the development of motor complications induced by L‐DOPA treatment. Synapse 52:218–222, 2004. © 2004 Wiley‐Liss, Inc.

収録刊行物

• Synapse

  Synapse 52 (3), 218-222, 2004-03-25

  Wiley

キーワード

• Cellular and Molecular Neuroscience

詳細情報

• CRID: 1361981471081583104
• NII論文ID: 30008333302
• DOI: 10.1002/syn.20011
• ISSN: 10982396
• ISSN: 08874476
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fsyn.20011
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1002/syn.20011
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