Imaging endogenous dopamine competition with [<sup>11</sup>C]raclopride in the human brain

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<jats:title>Abstract</jats:title><jats:p>This study images dopamine release in response to a neurochemically specific challenge with the psychostimulant drug methylphenidate. Changes in synaptic dopamine induced by methylphenidate were evaluated with positron emission tomography and [<jats:sup>11</jats:sup>C]raclopride, a D<jats:sub>2</jats:sub> receptor radioligand that is sensitive to endogenous dopamine. Methylphenidate significantly decreased striatal [<jats:sup>11</jats:sup>C]raclopride binding. The decrease was variable and was negatively correlated with age. Mood and anxiety at baseline, were also correlated with methylphenidate‐induced DA changes. This strategy provides a tool to investigate the responsiveness of the dopamine system in the normal and diseased human brain and to investigate the neurochemical correlates of behavior. © 1994 Wiley‐Liss, Inc.</jats:p>

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  • Synapse

    Synapse 16 (4), 255-262, 1994-04

    Wiley

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