Relationship between bone marrow cellularity and apparent diffusion coefficient

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<jats:title>Abstract</jats:title><jats:p>This study was performed to determine if there is a relationship between apparent diffusion coefficient (ADC) and cellularity of bone marrow of the posterior ilium. Four groups of various marrow cellularity underwent diffusion‐weighted echo‐planar imaging: 1) adults with normal hypocellularity (21 patients); 2) adults with normal normocellularity (13 patients); 3) young children with normal hypercellularity (5 patients); and 4) adults with lymphoma‐related hypercellularity (3 patients). In all adults, marrow cellularity was confirmed by uni‐or bilateral bone marrow biopsies. In children, the iliac marrow was presumed hypercellular because of their ages. A total of 66 ADC values of bone marrow calculated from diffusion‐weighted images with b‐values of 30 and 300 seconds/mm<jats:sup>2</jats:sup> was evaluated. Hypercellular marrow (normal and lymphoma‐related) showed the highest mean ADC, and hypocellular the lowest ADC. Statistically significant differences were found between three groups of normal marrow: hypocellular, normocellular, and hypercellular. There is a positive correlation between ADC and cellularity of bone marrow. J. Magn. Reson. Imaging 2001;13:757–760. © 2001 Wiley‐Liss, Inc.</jats:p>

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