The neurobiology, diagnosis, and treatment of narcolepsy

• Thomas E. Scammell

抄録

Narcolepsy is a common cause of chronic sleepiness distinguished by intrusions into wakefulness of physiological aspects of rapid eye movement sleep such as cataplexy and hallucinations. Recent advances provide compelling evidence that narcolepsy may be a neurodegenerative or autoimmune disorder resulting in a loss of hypothalamic neurons containing the neuropeptide orexin (also known as hypocretin). Because orexin promotes wakefulness and inhibits rapid eye movement sleep, its absence may permit inappropriate transitions between wakefulness and sleep. These discoveries have considerably improved our understanding of the neurobiology of sleep and should foster the development of rational treatments for a variety of sleep disorders. Ann Neurol 2003

収録刊行物

• Annals of Neurology

  Annals of Neurology 53 (2), 154-166, 2003-01-23

  Wiley

キーワード

• Neurology (clinical)
• Neurology

詳細情報

• CRID: 1360292619596296576
• NII論文ID: 30008829915
• DOI: 10.1002/ana.10444
• ISSN: 15318249
• ISSN: 03645134
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.10444
• データソース種別:
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  • CiNii Articles