Epileptiform Electroencephalogram during Mask Induction of Anesthesia with Sevoflurane
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- Arvi Yli-Hankala
- Associate Professor of Anesthesia, Department of Obstetrics and Gynecology, Helsinki University Central Hospital.
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- Anne Vakkuri
- Staff Anesthesiologist, Department of Obstetrics and Gynecology, Helsinki University Central Hospital.
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- Mika Särkelä
- Research Scientist, Department of Anesthesiology, Oulu University Hospital, Oulu, Finland.
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- Leena Lindgren
- Associate Professor of Anesthesia, IV Department of Surgery, Helsinki University Central Hospital.
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- Kari Korttila
- Professor of Anesthesia and Critical Care, Department of Obstetrics and Gynecology, Helsinki University Central Hospital.
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- Ville Jäntti
- Associate Professor of Clinical Neurophysiology, Department of Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland.
抄録
<jats:sec> <jats:title>Background</jats:title> <jats:p>Sevoflurane is suggested as a suitable anesthetic agent for mask induction in adults. The authors recently found that hyperventilation during sevoflurane-nitrous oxide-oxygen mask induction is associated with cardiovascular hyperdynamic response. We tested the hypothesis that the hyperdynamic response can be explained by electroencephalography (EEG) findings.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Thirty women were randomly allocated to receive sevoflurane-nitrous oxygen-oxygen mask induction using a single-breath method, followed by either spontaneous breathing (n = 15) or controlled hyperventilation (n = 15) for 6 min. EEG was recorded. Blood pressure and heart rate were recorded at 1-min intervals.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Epileptiform EEG activity (spikes or polyspikes) was seen in all patients with controlled hyperventilation, and in seven patients with spontaneous breathing (P < 0.01). Jerking movements were seen in three patients with controlled hyperventilation. In the controlled hyperventilation group, heart rate increased 54% from baseline at 4 min after induction (P < 0.001). Mean arterial pressure increased 17% (P < 0.05), peaking at 3 min. In the spontaneous breathing group, heart rate showed no change, and mean arterial pressure decreased by 14% (P < 0.01) at 6 min. Heart rate and mean arterial pressure differed significantly between the groups from 2 min after beginning of the induction to the end of the trial. An increase in heart rate of more than 30% from baseline always was associated with epileptiform EEG activity.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Sevoflurane mask induction elicits epileptiform EEG patterns. These are associated with an increase in heart rate in patients with controlled hyperventilation and also during spontaneous breathing of sevoflurane.</jats:p> </jats:sec>
収録刊行物
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- Anesthesiology
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Anesthesiology 91 (6), 1596-1596, 1999-12-01
Ovid Technologies (Wolters Kluwer Health)
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詳細情報 詳細情報について
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- CRID
- 1363388844092475904
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- NII論文ID
- 30009125920
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- ISSN
- 00033022
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- データソース種別
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